Bunnage, Mark E.; Burke, Anthony J.; Davies, Stephen G.; Goodwin, Christopher J. published the artcile< Asymmetric synthesis of (2S,3R)-3-amino-2-hydroxydecanoic acid: the unknown amino acid component of microginin>, Application In Synthesis of 104322-63-6, the main research area is asym synthesis aminohydroxydecanoic acid; absolute configuration microginin aminohydroxydecanoic acid.
3-Amino-2-hydroxydecanoic acid (AHDA) is an unusual amino acid purported to occur in the recently isolated angiotensin-converting enzyme inhibitor microginin. In order to elucidate the stereochem. of the naturally occurring material, and thus complete the structural assignment of microginin, both the (2R,3R)-anti-diastereoisomer and the (2S,3R)-syn-diastereoisomer of AHDA have been prepared Comparison of the 1H and 13C NMR spectroscopic data of the synthetic amino acids with that reported for the naturally occurring material indicates that the relative stereochem. of the AHDA found in microginin is syn. The absolute stereochem. of the natural amino acid is shown to be (2S,3R) by comparison of its reported CD spectrum with that recorded for the synthetic material prepared herein.
Tetrahedron: Asymmetry published new progress about Absolute configuration. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Application In Synthesis of 104322-63-6.
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com