The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Amino-6-methylpyrimidine-4-thiol( cas:6307-44-4 ) is researched.Recommanded Product: 2-Amino-6-methylpyrimidine-4-thiol.Hurst, Derek T.; Beaumont, Claire; Jones, Derek T. E.; Kingsley, Deborah A.; Partridge, Julian D.; Rutherford, Trevor J. published the article 《The chemistry of pyrimidinethiols. II. The preparation and reactions of some 2-arenecarbonylmethylthiopyrimidines》 about this compound( cas:6307-44-4 ) in Australian Journal of Chemistry. Keywords: pyrimidinone phenacylthio; phenacylthiopyrimidinone. Let’s learn more about this compound (cas:6307-44-4).
2-Pyrimidinethiones were treated with phenacyl halides to give (phenacylthio)pyrimidines I (R1= Ph, tolyl, halophenyl, anisyl, dimethyoxyphenyl, O2NC6H4, biphenyl, Cl2C6H3, naphthyl; R2 = Me, H, Ph, Pr, NH2). Some I were heated in Ph2O to give phenacylidenepyrimidinones II (R3 = Ph, tolyl, halophenyl, anisyl, dimethyoxyphenyl, O2NC6H4, biphenylyl, naphthyl; R4 = Me, H, Pr).
The article 《The chemistry of pyrimidinethiols. II. The preparation and reactions of some 2-arenecarbonylmethylthiopyrimidines》 also mentions many details about this compound(6307-44-4)Recommanded Product: 2-Amino-6-methylpyrimidine-4-thiol, you can pay attention to it, because details determine success or failure
Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com