Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Amino-6-methylpyrimidine-4-thiol, is researched, Molecular C5H7N3S, CAS is 6307-44-4, about Quantum Chemistry, NMR Spectroscopy, and Single-Crystal Diffractometry Methods in the Analysis of Protonation Pathways of 2-Amino-4-benzylsulfanyl-6-methylpyrimidines.Application In Synthesis of 2-Amino-6-methylpyrimidine-4-thiol.
Protonation pathways of 2-amino-4-benzylsulfanyl-6-methylpyrimidines have been investigated by means of semiempirical PM3 quantum-chem. simulation, 13C NMR spectroscopy, and single-crystal diffractometry methods. In the gas phase and in the bipolar aprotic solvent, the protonation involves the N1 atom. The protonation in the crystalline state is characterized by the formation of a branched system of H-bonds, involving the protons of the amino group besides the mentioned nitrogen atom.
Although many compounds look similar to this compound(6307-44-4)Application In Synthesis of 2-Amino-6-methylpyrimidine-4-thiol, numerous studies have shown that this compound(SMILES:SC1=CC(C)=NC(N)=N1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com