The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: tert-Butyl (6-chloro-4-iodopyridin-3-yl)carbamate(SMILESS: O=C(OC(C)(C)C)NC1=C(I)C=C(Cl)N=C1,cas:400777-00-6) is researched.Category: isothiazole. The article 《Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:400777-00-6).
During a program directed at selective NK1 receptor antagonists, we serendipitously discovered an NK1 receptor ligand with addnl. affinity for the NK3 receptor. Recognising an opportunity for a drug discovery program aiming for dual NK1/NK3 receptor antagonists, we prepared a series of analogs from a novel, versatile building block. From this series emerged compounds with high and balanced affinities for the NK1 and the NK3 receptors. Typical representatives of this series were active in the gerbil foot tapping assay after oral administration.
After consulting a lot of data, we found that this compound(400777-00-6)Reference of tert-Butyl (6-chloro-4-iodopyridin-3-yl)carbamate can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com