Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 560-09-8, is researched, SMILESS is CC1(C)[C@@H](CC[C@]1(C)C(O)=O)C(O)=O, Molecular C10H16O4Journal, Zhongguo Gonggong Weisheng called Protective effect of α-lipoic acid on diabetes cardiomyopathy in rats, Author is Kang, Yaping; Wang, Guoxian; Wei, Xiaogang, the main research direction is alpha lipoic acid diabetes cardiomyopathy matrix metalloproteinase.COA of Formula: C10H16O4.
The protective effect of α-lipoic acid (ALA) on diabetes cardiomyopathy and its mechanism were explored. SD rats were randomly divided into normal control, diabetes model, low, moderate and high dose ALA treatment groups with a peritoneal injection of streptozotocin (STZ) of 60 mg/kg. The rats in ALA treatment groups were administrated by gavage with ALA at the dosages of 15, 30, and 60 mg/kg a day for 12 wk. The contents of blood sugar and serum fructosamine were detected. Immunohistochem. method and western blot method were used to determine matrix metalloproteinase-9 (MMP-9), metalloproteinase-2 (MMP-2), and tissue inhibitors of matrix metalloproteinase-1 (TIMP-1) in myocardial tissue of the rats. Compared with those of the control group (4.62±1.03, 3.2±0.19), fasting blood glucose and serum fructosamine of the diabetic rats (25.45±3.24, 4.43±0.62) were significantly up-regulated (P<0.05). Cardiac function test showed that left ventricular end-diastolic pressure (LVEDP) increased and left ventricular systolic pressure (LVSP), ±dp/dtmax declined significantly in diabetes rats compared with those of the control rats (P<0.05 for all) and the protein expressions of MMP-2 (68.9±4.35), MMP-9 (87.38±11.10), TIMP-1 (81.82±9.61), and MMP-9/TIMP-1 (1.05±0.06) were also significantly up-regulated in the diabetic rats (P<0.05 for all). Compared with the diabetic group, fasting blood glucose and serum fructosamine of the ALA treated rats were significantly decreased (P<0.05 for all) and LVEDP (5.60±0.98 mmHg) decreased significantly (P<0.05) and LVSP (127.55±5.45 mmHg) elevated (P<0.05). The protein expressions of MMP-2 (62.26), MMP-9 (76.78), TIMP-1 (72.87) and MMP-9/TIMP-1 (1.03) of ALA treated rats were significantly decreased compared to those of the diabetic model rats (P<0.05 for all). ALA had protective effect on diabetic cardiomyopathy through regulating MMPs and TIMP-1. Compounds in my other articles are similar to this one((1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid)COA of Formula: C10H16O4, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com