Day: April 15, 2022

Formula: Al2H8O13S3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Aluminum(III) sulfate xhydrate, is researched, Molecular Al2H8O13S3, CAS is 17927-65-0, about Preparation of hollow zeolites with aliphatic polyols under hydrothermal conditions. Author is Chen, Qing-chun.

Taking al2(SO4)3·(14∼18)H2O and Na2SiO3·5H2O as main raw materials, several kinds of fine powders were prepared by using simple hydrothermal synthesis method. The XRD tests showed that one kind of the powders was composite of analcime and sodalite, and its SEM images showed that the fine powders were uniform hollow spheres with diameter under 5 μm. The other two kinds of powders were zeolite P, and their SEM images showed that they were hollow octahedrons with diameter of around 30 μm.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Erkin, A. V.; Krutikov, V. I. published the article 《N-(3-Sulfanylmethyl-4H-1,2,4-triazol-4-yl)-2-sulfanylacetamide Containing Terminal 2-Amino-6-methylpyrimidin-4-yl Fragments. Synthesis from 2-[(2-Amino-6-methylpyrimidin-4-yl)sulfanyl]acetohydrazide and Triethyl Orthoformate》. Keywords: amino methylpyrimidinyl sulfanylacetohydrazide preparation triethyl orthoformate heterocyclization; methyl aminopyrimidinyl sulfanylmethyltriazoloacetamide preparation.They researched the compound: 2-Amino-6-methylpyrimidine-4-thiol( cas:6307-44-4 ).SDS of cas: 6307-44-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:6307-44-4) here.

2-[(2-Amino-6-methylpyrimidin-4-yl)sulfanyl]acetohydrazide reacted with tri-Et orthoformate at a molar ratio of 1:1 to give 2-[(2-amino-6-methylpyrimidin-4-yl)sulfanyl]-N-{3-[(2-amino-6-methylpyrimidin-4-yl)sulfanylmethyl]-4H-1,2,4-triazol-4-yl}acetamide.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide, is researched, Molecular C7H11NO3S, CAS is 119639-24-6, about Tilcotil studies. Part 2. [4 + 2] Additions with isothiazol-3(2H)-one 1,1-dioxide, the main research direction is bromosiothiazole dioxide Diels Alder siloxybutadiene; oxazole isothiazolone dioxide Diels Alder; saccharin sweetening agent; pyridoisothiazole; oxicam; tilcotil; piroxicam derivative.COA of Formula: C7H11NO3S.

The isothiazoles I (R = CMe3, CH2CO2Et, R1 = Br) are not only dipolarophiles but also reactive and versatile dienophiles, especially with oxy-substituted 1,3-butadienes, I readily combine in Diels-Alder fashion; the regiospecificity of the addition is governed by the carbonyl group of the dienophile, whereas the SO2 group can be ignored for the purpose of predicting regioselectivity. Upon dehydrobromination of the [4 + 2] adducts with DBN, the cycloaromatization process is completed, generating saccharin-like compounds Besides the parent saccharin, several hydroxylated derivatives, e.g., II (R2 = OH, R3 = H; R2 = R3 = OH) have been synthesized by this new method. II are of potential interest as non-nutritive sweetening agents. In an alternative version of this principle, the isothiazole I (R = CMe3, CH2CO2Et, CH2C6H4OMe-4, R1 = H) is reacted with the oxazole III, affording, after acid-promoted rearrangement, pyrido-annulated isothiazoles IV. Since both processes generate saccharin-related structures, they may serve in syntheses of oxicams and analogs of ipsapirone. To demonstrate the viability of the approach one representative of each series, has been converted to an oxicam.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

SDS of cas: 560-09-8. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid, is researched, Molecular C10H16O4, CAS is 560-09-8, about Oriented Circular Dichroism Analysis of Chiral Surface-Anchored Metal-Organic Frameworks Grown by Liquid-Phase Epitaxy and upon Loading with Chiral Guest Compounds. Author is Gu, Zhi-Gang; Buerck, Jochen; Bihlmeier, Angela; Liu, Jinxuan; Shekhah, Osama; Weidler, Peter G.; Azucena, Carlos; Wang, Zhengbang; Heissler, Stefan; Gliemann, Hartmut; Klopper, Wim; Ulrich, Anne S.; Woell, Christof.

Oriented CD (OCD) is explored and successfully applied to study chiral surface-anchored metal-organic frameworks (SURMOFs) based on camphoric acid (D- and Lcam) [Cu2(Dcam)2x(Lcam)2-2x(dabco)]n (dabco = 1,4-diazabicyclo-[2.2.2]-octane). The three-dimensional chiral SURMOFs with high-quality orientation were grown on quartz glass plates by using a layer-by-layer LPE method. The growth orientation, as determined by XRD, could be switched between the [001] and [110] direction by using either OH- or COOH-terminated substrates. These SURMOFs were characterized by using OCD, which confirmed the ratio as well as the orientation of the enantiomeric linker mols. Theor. computations demonstrate that the OCD band intensities of the enantiopure [Cu2(Dcam)2(dabco)]n grown in different orientations are a direct result of the anisotropic nature of the chiral SURMOFs. Finally, the enantiopure [Cu2(Dcam)2(dabco)]n and [Cu2(Lcam)2(dabco)]n SURMOFs were loaded with the two chiral forms of Et lactate [(+)-ethyl-D-lactate and (-)-ethyl-L-lactate]. An enantioselective enrichment of >60% was observed by OCD when the chiral host scaffold was loaded from the racemic mixture

This literature about this compound(560-09-8)SDS of cas: 560-09-8has given us a lot of inspiration, and I hope that the research on this compound((1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Category: isothiazole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide, is researched, Molecular C7H11NO3S, CAS is 119639-24-6, about Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors. Author is Sparks, Richard B.; Polam, Padmaja; Zhu, Wenyu; Crawley, Matthew L.; Takvorian, Amy; McLaughlin, Erin; Wei, Min; Ala, Paul J.; Gonneville, Lucie; Taylor, Nancy; Li, Yanlong; Wynn, Richard; Burn, Timothy C.; Liu, Phillip C. C.; Combs, Andrew P..

Benzothiazole benzimidazole (S)-isothiazolidinone ((S)-IZD) derivatives 5 were discovered through a peptidomimetic modification of the tripeptide (S)-IZD protein tyrosine phosphatase 1B (PTP1B) inhibitor 1. These derivatives are potent, competitive, and reversible inhibitors of PTP1B with improved caco-2 permeability. An X-ray co-crystal structure of inhibitor 5/PTP1B at 2.2 Å resolution demonstrated that the benzothiazole benzimidazole forms bi-dentate H-bonds to Asp48, and the benzothiazole interacts with the surface of the protein in a solvent exposed region towards the C-site. The design, synthesis, and SAR of this novel series of benzothiazole benzimidazole containing (S)-IZD inhibitors of PTP1B are presented herein.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com