Usami, Atsushi; Motooka, Ryota; Miyazawa, Mitsuo published the article 《Highly selective biotransformation of (+)-(1S)- and (-)-(1R)-camphorquinone by Aspergillus wentii》. Keywords: Aspergillus selective biotransformation camphorquinone.They researched the compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid( cas:560-09-8 ).Application In Synthesis of (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:560-09-8) here.
To clarify the structures of biotransformation products and metabolic pathways, the biotransformation of monoterpenoids, (+)- and (-)-camphorquinone (1a and b), has been investigated using Aspergillus wentii as a biocatalyst. Compound 1a was converted to (-)-(2S)-exo-hydroxycamphor (2a), (-)-(2S)-endo-hydroxycamphor (3a), (-)-(3S)-exo-hydroxycamphor (4a), (-)-(3S)-endo-hydroxycamphor (5a), and (+)-camphoric acid (6a). Compound 1b was converted to (+)-(2R)-exo-hydroxycamphor (2b), (+)-(2R)-endo-hydroxycamphor (3b), (+)-(3R)-exo-hydroxycamphor (4b), (+)-(3R)-endo-hydroxycamphor (5b), and (-)-camphoric acid (6b). Compound 1a mainly produced 2a (65.0%) with stereoselectivity, whereas 1b afforded 3b (84.3%) with high stereoselectivity. These structures were confirmed by gas chromatog.-mass spectrometry, IR, 1H NMR (NMR), and 13C NMR spectral data. The products illustrate the marked ability of A. wentii for enzymic oxidation and ketone reduction
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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com