The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Amino-6-methylpyrimidine-4-thiol( cas:6307-44-4 ) is researched.Quality Control of 2-Amino-6-methylpyrimidine-4-thiol.Felczak, Krzysztof; Bretner, Maria; Kulikowski, Tadeusz; Shugar, David published the article 《High-yield regioselective thiation of biologically important pyrimidinones, dihydropyrimidinones and their ribo, 2′-deoxyribo and 2′,3′-dideoxyribo nucleosides》 about this compound( cas:6307-44-4 ) in Nucleosides & Nucleotides. Keywords: pyrimidinone regioselective thiation Lawesson reagent; nucleoside pyrimidinone regioselective thiation Lawesson reagent. Let’s learn more about this compound (cas:6307-44-4).
Convenient and high-yield regioselective thiation procedures based on the use of the Lawesson reagent in different solvents, are described for conversion of the 2- and 4-keto, and 2,4-diketo pyrimidines to the corresponding 2(4)-thio, and 2,4-dithio, derivatives This method is applicable to thiation of the 4-keto groups of 5,6-dihydropyrimidinones and pyrimidine nucleosides. The mild reaction conditions employed are such that it is the method of choice for compounds with labile glycosidic bonds, of choice for compounds with labile glycosidic bonds, such as 5,6-dihydropyrimidine nucleosides and the 2′,3′-dideoxynucleosides currently of interest as antiretroviral, including anti-HIV, agents.
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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com