Why do aromatic interactions matter of compound: 119639-24-6

In addition to the literature in the link below, there is a lot of literature about this compound(2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide)Formula: C7H11NO3S, illustrating the importance and wide applicability of this compound(119639-24-6).

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors, published in 2007-02-01, which mentions a compound: 119639-24-6, Name is 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide, Molecular C7H11NO3S, Formula: C7H11NO3S.

Benzothiazole benzimidazole (S)-isothiazolidinone ((S)-IZD) derivatives 5 were discovered through a peptidomimetic modification of the tripeptide (S)-IZD protein tyrosine phosphatase 1B (PTP1B) inhibitor 1. These derivatives are potent, competitive, and reversible inhibitors of PTP1B with improved caco-2 permeability. An X-ray co-crystal structure of inhibitor 5/PTP1B at 2.2 Å resolution demonstrated that the benzothiazole benzimidazole forms bi-dentate H-bonds to Asp48, and the benzothiazole interacts with the surface of the protein in a solvent exposed region towards the C-site. The design, synthesis, and SAR of this novel series of benzothiazole benzimidazole containing (S)-IZD inhibitors of PTP1B are presented herein.

In addition to the literature in the link below, there is a lot of literature about this compound(2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide)Formula: C7H11NO3S, illustrating the importance and wide applicability of this compound(119639-24-6).

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com