The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid( cas:560-09-8 ) is researched.Application of 560-09-8.Usami, Atsushi; Motooka, Ryota; Miyazawa, Mitsuo published the article 《Highly selective biotransformation of (+)-(1S)- and (-)-(1R)-camphorquinone by Aspergillus wentii》 about this compound( cas:560-09-8 ) in Biocatalysis and Biotransformation. Keywords: Aspergillus selective biotransformation camphorquinone. Let’s learn more about this compound (cas:560-09-8).
To clarify the structures of biotransformation products and metabolic pathways, the biotransformation of monoterpenoids, (+)- and (-)-camphorquinone (1a and b), has been investigated using Aspergillus wentii as a biocatalyst. Compound 1a was converted to (-)-(2S)-exo-hydroxycamphor (2a), (-)-(2S)-endo-hydroxycamphor (3a), (-)-(3S)-exo-hydroxycamphor (4a), (-)-(3S)-endo-hydroxycamphor (5a), and (+)-camphoric acid (6a). Compound 1b was converted to (+)-(2R)-exo-hydroxycamphor (2b), (+)-(2R)-endo-hydroxycamphor (3b), (+)-(3R)-exo-hydroxycamphor (4b), (+)-(3R)-endo-hydroxycamphor (5b), and (-)-camphoric acid (6b). Compound 1a mainly produced 2a (65.0%) with stereoselectivity, whereas 1b afforded 3b (84.3%) with high stereoselectivity. These structures were confirmed by gas chromatog.-mass spectrometry, IR, 1H NMR (NMR), and 13C NMR spectral data. The products illustrate the marked ability of A. wentii for enzymic oxidation and ketone reduction
In addition to the literature in the link below, there is a lot of literature about this compound((1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid)Application of 560-09-8, illustrating the importance and wide applicability of this compound(560-09-8).
Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com