Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zhongguo Gonggong Weisheng called Protective effect of α-lipoic acid on diabetes cardiomyopathy in rats, Author is Kang, Yaping; Wang, Guoxian; Wei, Xiaogang, which mentions a compound: 560-09-8, SMILESS is CC1(C)[C@@H](CC[C@]1(C)C(O)=O)C(O)=O, Molecular C10H16O4, SDS of cas: 560-09-8.
The protective effect of α-lipoic acid (ALA) on diabetes cardiomyopathy and its mechanism were explored. SD rats were randomly divided into normal control, diabetes model, low, moderate and high dose ALA treatment groups with a peritoneal injection of streptozotocin (STZ) of 60 mg/kg. The rats in ALA treatment groups were administrated by gavage with ALA at the dosages of 15, 30, and 60 mg/kg a day for 12 wk. The contents of blood sugar and serum fructosamine were detected. Immunohistochem. method and western blot method were used to determine matrix metalloproteinase-9 (MMP-9), metalloproteinase-2 (MMP-2), and tissue inhibitors of matrix metalloproteinase-1 (TIMP-1) in myocardial tissue of the rats. Compared with those of the control group (4.62±1.03, 3.2±0.19), fasting blood glucose and serum fructosamine of the diabetic rats (25.45±3.24, 4.43±0.62) were significantly up-regulated (P<0.05). Cardiac function test showed that left ventricular end-diastolic pressure (LVEDP) increased and left ventricular systolic pressure (LVSP), ±dp/dtmax declined significantly in diabetes rats compared with those of the control rats (P<0.05 for all) and the protein expressions of MMP-2 (68.9±4.35), MMP-9 (87.38±11.10), TIMP-1 (81.82±9.61), and MMP-9/TIMP-1 (1.05±0.06) were also significantly up-regulated in the diabetic rats (P<0.05 for all). Compared with the diabetic group, fasting blood glucose and serum fructosamine of the ALA treated rats were significantly decreased (P<0.05 for all) and LVEDP (5.60±0.98 mmHg) decreased significantly (P<0.05) and LVSP (127.55±5.45 mmHg) elevated (P<0.05). The protein expressions of MMP-2 (62.26), MMP-9 (76.78), TIMP-1 (72.87) and MMP-9/TIMP-1 (1.03) of ALA treated rats were significantly decreased compared to those of the diabetic model rats (P<0.05 for all). ALA had protective effect on diabetic cardiomyopathy through regulating MMPs and TIMP-1. Here is just a brief introduction to this compound(560-09-8)SDS of cas: 560-09-8, more information about the compound((1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid) is in the article, you can click the link below.
Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com