An update on the compound challenge: 400777-00-6

There is still a lot of research devoted to this compound(SMILES:O=C(OC(C)(C)C)NC1=C(I)C=C(Cl)N=C1)Recommanded Product: 400777-00-6, and with the development of science, more effects of this compound(400777-00-6) can be discovered.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A Ruthenium(II) Complex as a Luminescent Probe for DNA Mismatches and Abasic Sites, published in 2017-07-17, which mentions a compound: 400777-00-6, Name is tert-Butyl (6-chloro-4-iodopyridin-3-yl)carbamate, Molecular C10H12ClIN2O2, Recommanded Product: 400777-00-6.

[Ru(bpy)2(BNIQ)]2+ (BNIQ = Benzo[c][1,7]naphthyridine-1-isoquinoline), which incorporates the sterically expansive BNIQ ligand, is a highly selective luminescent probe for DNA mismatches and abasic sites, possessing a 500-fold higher binding affinity toward these destabilized regions relative to well-matched base pairs. As a result of this higher binding affinity, the complex exhibits an enhanced steady-state emission in the presence of DNA duplexes containing a single base mismatch or abasic site compared to fully well-matched DNA. Luminescence quenching experiments with Cu(phen)22+ and [Fe(CN)6]3- implicate binding of the complex to a mismatch from the minor groove via metalloinsertion. The emission response of the complex to different single base mismatches, binding preferentially to the more destabilized mismatches, is also consistent with binding by metalloinsertion. This work shows that high selectivity toward destabilized regions in duplex DNA can be achieved through the rational design of a complex with a sterically expansive aromatic ligand.

There is still a lot of research devoted to this compound(SMILES:O=C(OC(C)(C)C)NC1=C(I)C=C(Cl)N=C1)Recommanded Product: 400777-00-6, and with the development of science, more effects of this compound(400777-00-6) can be discovered.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com