Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 400777-00-6, is researched, SMILESS is O=C(OC(C)(C)C)NC1=C(I)C=C(Cl)N=C1, Molecular C10H12ClIN2O2Journal, Article, Inorganic Chemistry called A Ruthenium(II) Complex as a Luminescent Probe for DNA Mismatches and Abasic Sites, Author is Boynton, Adam N.; Marcelis, Lionel; McConnell, Anna J.; Barton, Jacqueline K., the main research direction is ruthenium complex luminescence DNA mismatch.Product Details of 400777-00-6.
[Ru(bpy)2(BNIQ)]2+ (BNIQ = Benzo[c][1,7]naphthyridine-1-isoquinoline), which incorporates the sterically expansive BNIQ ligand, is a highly selective luminescent probe for DNA mismatches and abasic sites, possessing a 500-fold higher binding affinity toward these destabilized regions relative to well-matched base pairs. As a result of this higher binding affinity, the complex exhibits an enhanced steady-state emission in the presence of DNA duplexes containing a single base mismatch or abasic site compared to fully well-matched DNA. Luminescence quenching experiments with Cu(phen)22+ and [Fe(CN)6]3- implicate binding of the complex to a mismatch from the minor groove via metalloinsertion. The emission response of the complex to different single base mismatches, binding preferentially to the more destabilized mismatches, is also consistent with binding by metalloinsertion. This work shows that high selectivity toward destabilized regions in duplex DNA can be achieved through the rational design of a complex with a sterically expansive aromatic ligand.
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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com