The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide(SMILESS: O=C(C=C1)N(C(C)(C)C)S1(=O)=O,cas:119639-24-6) is researched.Synthetic Route of C9H9NO. The article 《Tilcotil studies. [3+2]Additions with isothiazol-3(2H)-one 1,1-dioxide》 in relation to this compound, is published in Helvetica Chimica Acta. Let’s take a look at the latest research on this compound (cas:119639-24-6).
Derivatives of isothiazol-3(2H)-one 1,1-dioxide (I) react regiospecifically with 1,3-dipolar agents. The main regiocontrolling factor is the C:O group of the dipolarophile. The topol. of the adducts is also in general agreement with predictions based on perturbation theory. Several adducts can be aromatized to heterocyclic equivalents of saccharin, and can then be elaborated into structural analogs of tenoxicam (Tilcotil) and piroxicam (Feldene).
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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com