Extracurricular laboratory: Synthetic route of 6307-44-4

As far as I know, this compound(6307-44-4)Name: 2-Amino-6-methylpyrimidine-4-thiol can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Name: 2-Amino-6-methylpyrimidine-4-thiol. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Amino-6-methylpyrimidine-4-thiol, is researched, Molecular C5H7N3S, CAS is 6307-44-4, about High-yield regioselective thiation of biologically important pyrimidinones, dihydropyrimidinones and their ribo, 2′-deoxyribo and 2′,3′-dideoxyribo nucleosides. Author is Felczak, Krzysztof; Bretner, Maria; Kulikowski, Tadeusz; Shugar, David.

Convenient and high-yield regioselective thiation procedures based on the use of the Lawesson reagent in different solvents, are described for conversion of the 2- and 4-keto, and 2,4-diketo pyrimidines to the corresponding 2(4)-thio, and 2,4-dithio, derivatives This method is applicable to thiation of the 4-keto groups of 5,6-dihydropyrimidinones and pyrimidine nucleosides. The mild reaction conditions employed are such that it is the method of choice for compounds with labile glycosidic bonds, of choice for compounds with labile glycosidic bonds, such as 5,6-dihydropyrimidine nucleosides and the 2′,3′-dideoxynucleosides currently of interest as antiretroviral, including anti-HIV, agents.

As far as I know, this compound(6307-44-4)Name: 2-Amino-6-methylpyrimidine-4-thiol can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com