The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Configuration of the camphoric acids》. Authors are Walker, James; Wood, John K..The article about the compound:(1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acidcas:560-09-8,SMILESS:CC1(C)[C@@H](CC[C@]1(C)C(O)=O)C(O)=O).Application of 560-09-8. Through the article, more information about this compound (cas:560-09-8) is conveyed.
The molecule of camphoric acid contains two, and only two, asymmetric carbon atoms, that these carbon atoms are links in a closed carbon chain, and that each of them has a carboxyl group attached to it. It is further known that the asymmetric carbon atoms are not similar to each other, so that there can be no optical inactivity by internal compensation. To distinguish between these two asymmetric atoms, the prefixes ortho- and allo-, which are commonly used in application to the two carboxyl groups are employed. A discussion on the asymmetric carbon atom to which the ortho-carboxyl group is attached as the ortho-carbon atom, and of that to which the allo-carboxyl group is united as the allo-carbon atom, is presented.
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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com