So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wu, Yusheng; Sabbe, Katrien; De Clercq, Pierre; Vandewalle, Maurits; Bouillon, Roger; Verstuyf, Annemieke researched the compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid( cas:560-09-8 ).Reference of (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid.They published the article 《Vitamin D3: synthesis of seco C-9,11,21-trisnor-17-methyl-1α, 25-dihydroxyvitamin D3 analogues》 about this compound( cas:560-09-8 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: vitamin D3 analog antiproliferative antitumor calcemic effect preparation; trisnormethyldihydroxyvitamin D3 D ring analog preparation. We’ll tell you more about this compound (cas:560-09-8).
The synthesis and biol. activities of seco C-9,11,21-trisnor-17-methyl-1α,25-dihydroxyvitamin D3 analogs (D-ring analogs) are described. Synthesized analogs were evaluated for their affinity for the vitamin D receptor, in vivo calcemic effects in mice, and anti-proliferative activity in various cell lines.
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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com