An article Green, Mild, and Efficient Friedel-Crafts Benzylation of Scarcely Reactive Arenes and Heteroarenes under On-Water Conditions WOS:000466387800014 published article about PROTON ACCEPTOR GROUPS; X-RAY-DIFFRACTION; HYDROPHOBIC AMPLIFICATION; ORGANIC-REACTIONS; MICHAEL ADDITION; ALKYL; CATALYST; BENZENE; DIARYLMETHANES; ACCELERATION in [La Manna, Pellegrino; Soriente, Annunziata; De Rosa, Margherita; Buonerba, Antonio; Talotta, Carmen; Gaeta, Carmine; Neri, Placido] Univ Salerno, Dipartimento Chim & Biol A Zambelli, Via Giovanni Paolo II, I-84084 Salerno, Italy in 2019, Cited 98. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0. Product Details of 151-10-0
Metal-free Friedel-Crafts benzylation (FCB) of scarcely reactive arenes and heteroarenes was performed under on-water conditions by an environmentally sustainable procedure. The catalytic strategy exploits the hydrophobicity of the resorcinarene macrocycle 1 a. The proposed mechanism is based on the activation of benzyl chloride by H-bonding interactions with catalyst 1 a. In fact, under on-water conditions the hydrophobic amplification of the strength of the H-bonding interactions between the OH groups of the resorcinarene catalyst and the chlorine atom of benzyl chloride leads to polarization of the C-Cl bond, which consequently promotes electrophilic attack of the pi nucleophile. Thus, many arenes and heteroarenes were efficiently benzylated under mild on-water conditions by using resorcinarene 1 a as catalyst. The FCB of benzene is industrially relevant for the synthesis of diphenylmethane, and hence the on-water procedure was extended to the gram-scale synthesis of diphenylmethane, starting from benzene and benzyl chloride in the presence of resorcinarene catalyst 1 a.
Product Details of 151-10-0. Welcome to talk about 151-10-0, If you have any questions, you can contact La Manna, P; Soriente, A; De Rosa, M; Buonerba, A; Talotta, C; Gaeta, C; Neri, P or send Email.
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