An article Decarbonylative Sonogashira Cross-Coupling of Carboxylic Acids WOS:000664333200043 published article about CATALYZED HECK; ALKYNYLATION in [Liu, Chengwei; Szostak, Michal] Rutgers State Univ, Dept Chem, Newark, NJ 07102 USA in 2021, Cited 33. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Quality Control of 3-Methylbenzoic acid
Decarbonylative Sonogashira cross-coupling of carboxylic acids by palladium catalysis is presented. The carboxylic acid is activated in situ by the formation of a mixed anhydride and further decarbonylates using the Pd(OAc)(2)/Xantphos system to provide an aryl-Pd intermediate, which is intercepted by alkynes to access the traditional Pd(0)/(II) cycle using carboxylic acids as ubiquitous and orthogonal electrophilic cross-coupling partners. The methodology efficiently constructs new C(sp(2))-C(sp) bonds and can be applied to the derivatization of pharmaceuticals. Mechanistic studies give support to decarbonylation preceding transmetalation in this process.
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Reference:
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