I found the field of Chemistry very interesting. Saw the article Entry to 1,2,3,4-Tetrasubstituted Arenes through Addressing the Meta Constraint in the Palladium/Norbornene Catalysis published in 2020. Safety of Benzoic anhydride, Reprint Addresses Dong, GB (corresponding author), Univ Chicago, Dept Chem, 5735 S Ellis Ave, Chicago, IL 60637 USA.. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride
Arenes with four different contiguous substituents, i.e. 1,2,3,4-tetrasubstituted arenes, are commonly found in bioactive compounds, but they are nontrivial to access via conventional methods. Through addressing the meta constraint in the palladium/norbornene (Pd/NBE) cooperative catalysis, which is the difficulty of tolerating a sizable meta substituent in aryl halide substrates, here a modular and regioselective approach is realized for preparing 1,2,3,4-tetrasubstituted arenes. One key is the use of a C2-amide-substituted NBE, and a combined experimental and computational study reveals its role in promoting the NBE insertion and the ortho C-H metalation steps. The scope is broad: a variety of electrophiles and nucleophiles could be introduced to the ortho and ipso positions, respectively, with 1,4-disubstituted aryl halides, leading to diverse unsymmetrical contiguous tetrasubstituted arenes. Application of this approach has been demonstrated in streamlined syntheses of several bioactive compounds.
Safety of Benzoic anhydride. Welcome to talk about 93-97-0, If you have any questions, you can contact Wang, JC; Zhou, Y; Xu, XL; Liu, P; Dong, GB or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com