SDS of cas: 93-97-0. I found the field of Plant Sciences; Pharmacology & Pharmacy very interesting. Saw the article Oleanolic Acid Derivatives as Potential Inhibitors of HIV-1 Protease published in 2019, Reprint Addresses Rivas, F; Parra, A (corresponding author), Univ Granada, Fac Ciencias, Dept Quim Organ, E-18071 Granada, Spain.; Reyes-Zurita, FJ (corresponding author), Univ Granada, Fac Ciencias, Dept Bioquim & Biol Mol 1, E-18071 Granada, Spain.. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride.
Pentacyclic triterpenes, such as oleanolic acid (I), are promising scaffolds for diversification through the use of combinatorial methods to obtain derivatives that improve their biological properties, increasing their bioavailability and enhancing their therapeutic efficacy. The purpose of this study was to evaluate the influence that derivatives of oleanolic acid, conjugated with one or two amino acids and an acyl group, might exert on HIV-1 protease inhibition. The in vitro studies conducted suggested that the presence of a carboxyacyl group generally improves the inhibition of HIV-1 protease, especially when a phthaloyl group is present, with IC50 concentration values below 5 mu M. The gain in activity of three 3-phthaloyl derivatives, with sub-micromolar IC50 values, was between 60- and 100-fold more active than oleanolic acid. A molecular docking study has also been performed to elucidate the mode of binding to the protease by these oleanolic acid derivatives. In general, the derivatives that exhibited the highest inhibitory activity of HIV-1 protease also showed the highest binding energies in docking simulations. The overall results suggest that the coupling of one or two amino acids and a phthaloyl group to oleanolic acid improves HIV-1 protease inhibition, implying that these triterpene derivatives may be promising antiviral agents against HIV.
SDS of cas: 93-97-0. Bye, fridends, I hope you can learn more about C14H10O3, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com