An article Entry to 1,2,3,4-Tetrasubstituted Arenes through Addressing the Meta Constraint in the Palladium/Norbornene Catalysis WOS:000514255300043 published article about ALKYLATION-ALKENYLATION REACTIONS; C-H FUNCTIONALIZATION; EFFICIENT SYNTHESIS; ARYL IODIDES; ARYLATION; PSYMBERIN; ACYLATION; ROUTE in [Wang, Jianchun; Zhou, Yun; Xu, Xiaolong; Dong, Guangbin] Univ Chicago, Dept Chem, 5735 S Ellis Ave, Chicago, IL 60637 USA; [Zhou, Yun] China Agr Univ, Dept Appl Chem, Beijing 100193, Peoples R China; [Xu, Xiaolong] ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China; [Liu, Peng] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA in 2020, Cited 51. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0. Category: isothiazole
Arenes with four different contiguous substituents, i.e. 1,2,3,4-tetrasubstituted arenes, are commonly found in bioactive compounds, but they are nontrivial to access via conventional methods. Through addressing the meta constraint in the palladium/norbornene (Pd/NBE) cooperative catalysis, which is the difficulty of tolerating a sizable meta substituent in aryl halide substrates, here a modular and regioselective approach is realized for preparing 1,2,3,4-tetrasubstituted arenes. One key is the use of a C2-amide-substituted NBE, and a combined experimental and computational study reveals its role in promoting the NBE insertion and the ortho C-H metalation steps. The scope is broad: a variety of electrophiles and nucleophiles could be introduced to the ortho and ipso positions, respectively, with 1,4-disubstituted aryl halides, leading to diverse unsymmetrical contiguous tetrasubstituted arenes. Application of this approach has been demonstrated in streamlined syntheses of several bioactive compounds.
Category: isothiazole. About Benzoic anhydride, If you have any questions, you can contact Wang, JC; Zhou, Y; Xu, XL; Liu, P; Dong, GB or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com