Safety of 3-Methylbenzoic acid. In 2020.0 BIOORG CHEM published article about MOLECULAR-FORCE FIELD; ORTHOGONAL MULTIPOLAR INTERACTIONS; BIOLOGICAL EVALUATION; STRATEGIC INCORPORATION; MEDICINAL CHEMISTRY; THROMBIN INHIBITORS; ANTICANCER AGENTS; FLUORINE SCAN; SECO-TAXOIDS; PHARMACEUTICALS in [Wang, Changwei; Wang, Xin; Sun, Yi; Taouil, Adam K.; Yan, Su; Ojima, Iwao] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA; [Wang, Changwei; Wang, Xin; Sun, Yi; Yan, Su; Botchkina, Galina I.; Ojima, Iwao] SUNY Stony Brook, Inst Chem Biol & Drug Discovery, Stony Brook, NY 11794 USA; [Wang, Changwei] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Drug Discovery Pipeline, Guangzhou 510530, Peoples R China; [Botchkina, Galina I.] SUNY Stony Brook, Dept Pathol, Renaissance Sch Med, Stony Brook, NY 11794 USA in 2020.0, Cited 80.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.
It has been shown that inclusion of CF3O and CHF2O groups to drug candidates often improve their pharmacological properties, especially metabolic stability, membrane permeability and PK profile. Moreover, the unique non-spherical structure of the OCHF2 group can provide interesting and beneficial characteristics. Accordingly, new 3rd-generation taxoids, bearing 3-OCF3 or 3-OCF2H (and 3-CH3 for comparison) at the C2 benzoate moiety, were synthesized and their potencies against drug-sensitive and drug-resistant cancer cell lines examined. In this study, our previous SAR studies on 3rd-generation taxoids were expanded to disclose that CH3, CF3O and CHF2O groups are well tolerated at this position and enhance potency, especially against MDR-cancer cell lines so that these taxoids can virtually overcome MDR. These new taxoids exhibit up to 7 times higher cytotoxicity (IC50) than paclitaxel against drug-sensitive cancer cell lines (MCF7 and LCC6-WT) and 2-3 orders of magnitude higher potency than paclitaxel against drug-resistant ovarian, breast and colon cancer cell lines with MDR-phenotype (NCI/ADR, LCC6-MDR and LDL-1), as well as pancreatic cancer cell line, CFPAC-1. Since it has been shown that a bulky group at this position reduces potency, it is noteworthy that rather bulky CF3O and CHF2O groups are well tolerated. Molecular modeling analysis indicated the favorable van der Waals interactions of CF3O and CHF2O groups in the binding site. It is also worthy of note that new taxoids, bearing a CHF2O group at the C2 benzoate position (1-06 series), exhibited the highest potencies against MDR-cancer cell lines and cancer stem cell (CSC)-enriched cancer cell lines. These new 3rd-generation taxoids are promising candidates for highly potent chemotherapeutic agents, as well as payloads for tumor-targeting drug conjugates such as antibody-drug conjugates (ADCs).
Safety of 3-Methylbenzoic acid. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com