Month: January 2022

Abdelaziz, OA; El Husseiny, WM; Selim, KB; Eisa, HM in [Abdelaziz, Ola A.; El Husseiny, Walaa M.; Selim, Khalid B.; Eisa, Hassan M.] Mansoura Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Mansoura 35516, Egypt published Dihydrofolate reductase inhibition effect of 5-substituted pyrido[2,3-d] pyrimidines: Synthesis, antitumor activity and molecular modeling study in 2019.0, Cited 46.0. Application In Synthesis of 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

A new series of pyrido[2,3-d] pyrimidines 3-18 bearing substitution at C-5 position was synthesized. All compounds were tested for their in vitro antitumor activity against five human cancer cell lines namely; hepatocellular carcinoma (HePG2), breast carcinoma (MCF-7), human prostate carcinoma (PC3), colorectal carcinoma (HCT-116), and cervical carcinoma (Hela) using doxorubicin as a positive control. Compounds 3, 4, 9, 11, 13, 14, 15 and 17 exhibited the highest antitumor activity against the tested cell lines and were selected to screen their enzymatic inhibition against dihydrofolate reductase enzyme (DHFR) compared with the reference drug methotrexate (MTX), to explain the probable mechanism of action of the observed anticancer activity. Compound 11 displayed the highest inhibitory activity (IC50 = 6.5 mu M) among the tested compounds in comparison with MTX (IC50 = 5.57 mu M). Also, compounds 13 and 14 showed high inhibitory activity against DHFR with IC50 values 7.1 and 8.7 mu M, respectively. Comparative molecular modeling study was performed between DHFR inhibitors 11, 13 and 14 of the highest activity and 10 of the lowest activity among the eight inhibitors against MTX. Docking studies into the active site of DHFR domain showed good agreement with the obtained biological results. Finally, compound 11 was found to be best antitumor, DHFR inhibitor, and it induced the process of apoptosis at Pre-G phase and cell cycle arrest at G2/M phase in MCF-7 cells.

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. Welcome to talk about 93-02-7, If you have any questions, you can contact Abdelaziz, OA; El Husseiny, WM; Selim, KB; Eisa, HM or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Allyl-Nickel Catalysis Enables Carbonyl Dehydrogenation and Oxidative Cycloalkenylation of Ketones published in 2019. Computed Properties of C14H10O3, Reprint Addresses Newhouse, TR (corresponding author), Yale Univ, Dept Chem, 225 Prospect St, New Haven, CT 06520 USA.. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride

We herein disclose the first report of a first-row transition metal-catalyzed alpha,beta-dehydrogenation of carbonyl compounds using allyl-nickel catalysis. This development overcomes several limitations of previously reported allyl-palladium-catalyzed oxidation, and is further leveraged for the development of an oxidative cycloalkenylation reaction that provides access to bicycloalkenones with fused, bridged, and spirocyclic ring systems using unactivated ketone and alkene precursors.

Bye, fridends, I hope you can learn more about C14H10O3, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C14H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about ENANTIOSELECTIVE SYNTHESIS; PHOSPHORUS LIGANDS; BRONSTED ACID; ALCOHOLS; ACTIVATION; BATCH; CATALYSIS; SECONDARY, Saw an article supported by the CERCA Programme/Generalitat de Catalunya; MINECO [CTQ2015-69136-R]; AGAUR/Generalitat de CatalunyaAgencia de Gestio D’Ajuts Universitaris de Recerca Agaur (AGAUR)Generalitat de Catalunya [2017 SGR 1139]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Lai, JS; Neyyappadath, RM; Smith, AD; Pericas, MA. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride. Name: Benzoic anhydride

A polystyrene-immobilized isothiourea has been applied to the enantioselective acylative kinetic resolution (KR) of monoacylated BINOL(s) with inexpensive isobutyric anhydride in batch and flow. High selectivity values (s=29 at 0 degrees C) and a remarkable stability of the catalytic system in the operation conditions have been recorded for unsubstituted BINOL. No significant loss of activity/selectivity is recorded after 10 consecutive KR cycles in batch. A continuous flow process has been implemented and operated with a 100 mmol (32.8 g) sample of racemic monoacetylated BINOL in dichloromethane solution in an 84 hours experiment with a packed bed reactor containing 1 g (f=0.37 mmol.g(-1)) of the functional resin (s=17-21). Residence time can be decreased to 10 min with the same reactor to achieve a conversion of 58% with a selectivity factor s=17 when a more highly functionalized catalyst (f=0.88 mmol.g(-1)) is used. This translates into a remarkable combined productivity of 5.5 mmol(prod) . mmol(cat)(-1) . h(-1).

Name: Benzoic anhydride. About Benzoic anhydride, If you have any questions, you can contact Lai, JS; Neyyappadath, RM; Smith, AD; Pericas, MA or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2020 J AM CHEM SOC published article about C-H ACTIVATION; ORTHO-ARYLATION; AMINO-ACIDS; BONDS; DIVERSIFICATION; CARBONYLATION; BIDENTATE; ROUTE in [Zhuang, Zhe; Yu, Jin-Quan] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA in 2020, Cited 38. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0. Recommanded Product: Benzoic anhydride

Prized for their ability to reliably forge stereocenters with precise regiocontrol from simple and abundant starting materials, substrate-directable enantioselective reactions are widely used in modern organic synthesis. As such, enantioselective C(sp(3))-H functionalization reactions directed by innate functional groups could provide new routes to introduce molecular complexity within the inert hydrocarbon moiety, but to date this approach has been met with little success. While free primary aliphatic amines are common, versatile intermediates in synthesis, they are traditionally unreactive in C(sp(3))-H activation reactions. Herein we report the Pd-catalyzed enantioselective C(sp(3))-H functionalization of free aliphatic amines (cyclopropylmethylamines) enabled by a chiral bidentate thioether ligand. This ligand’s privileged bidentate coordination mode and thioether motif favor the generation of the requisite mono(amine)-Pd(II) intermediate, thus enabling the enantioselective C-H activation of free amines. The resulting C-Pd(II) species could engage in either Pd(II)/Pd(IV) or Pd(II)/Pd(0) catalytic cycles, enabling access to a diverse range of products through (hetero)arylation, carbonylation, and olefination reactions. Consequently, this versatile reactivity offers medicinal chemists a general strategy to rapidly prepare and functionalize biologically relevant amines.

Welcome to talk about 93-97-0, If you have any questions, you can contact Zhuang, Z; Yu, JQ or send Email.. Recommanded Product: Benzoic anhydride

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Bomon, J; Bal, M; Achar, TK; Sergeyev, S; Wu, X; Wambacq, B; Lemiere, F; Sels, BF; Maes, BUW in ROYAL SOC CHEMISTRY published article about in [Bomon, Jeroen; Bal, Mathias; Achar, Tapas Kumar; Sergeyev, Sergey; Lemiere, Filip; Maes, Bert U. W.] Univ Antwerp, Dept Chem, Groenenborgerlaan 171, B-2020 Antwerp, Belgium; [Wu, Xian; Wambacq, Ben; Sels, Bert F.] Katholieke Univ Leuven, Ctr Sustainable Catalysis & Engn, Celestijnenlaan 200F, B-3001 Leuven, Belgium in 2021, Cited 104. Recommanded Product: 1,3-Dimethoxybenzene. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

A green, efficient and cheap demethylation reaction of aromatic methyl ethers with mineral acid (HCl or H2SO4) as a catalyst in high temperature pressurized water provided the corresponding aromatic alcohols (phenols, catechols, pyrogallols) in high yield. 4-Propylguaiacol was chosen as a model, given the various applications of the 4-propylcatechol reaction product. This demethylation reaction could be easily scaled and biorenewable 4-propylguaiacol from wood and clove oil could also be applied as a feedstock. Greenness of the developed method versus state-of-the-art demethylation reactions was assessed by performing a quantitative and qualitative Green Metrics analysis. Versatility of the method was shown on a variety of aromatic methyl ethers containing (biorenewable) substrates, yielding up to 99% of the corresponding aromatic alcohols, in most cases just requiring simple extraction as work-up.

About 1,3-Dimethoxybenzene, If you have any questions, you can contact Bomon, J; Bal, M; Achar, TK; Sergeyev, S; Wu, X; Wambacq, B; Lemiere, F; Sels, BF; Maes, BUW or concate me.. Recommanded Product: 1,3-Dimethoxybenzene

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Efficient Synthesis of Diarylmethylamines via Lewis Acid Catalyzed Friedel-Crafts Reactions of Donor-Acceptor Aziridines with N,N-Dialkylanilines WOS:000502820600012 published article about ASYMMETRIC 3+2 CYCLOADDITION; CHIRAL DIENE LIGANDS; H BOND ARYLATION; N-TOSYLAZIRIDINES; C-ARYLATION; N,N-DIALKYL-3-VINYLANILINES; DERIVATIVES; FUNCTIONALIZATION; TOSYLARYLIMINES; ALDEHYDES in [Kim, Yerin; Kwon, Yong Il; Kim, Sung-Gon] Kyonggi Univ, Dept Chem, 154-42 Gwanggyosan Ro, Suwon 16227, South Korea in 2020, Cited 57. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0. Category: isothiazole

A method for efficient and mild synthesis of diarylmethylamine scaffold, via Lewis acid catalyzed Friedel-Crafts reaction of donor-acceptor aziridines with N,N-dialkylanilines to afford a biologically important diarylmethylamine derivatives in high yields (up to 88%), is presented. This reaction is suitable for the synthesis of various diarylmethylamine derivatives and has a broad scope for electron-rich arenes, including dimethoxybenzene.

Category: isothiazole. Welcome to talk about 151-10-0, If you have any questions, you can contact Kim, Y; Kwon, YI; Kim, SG or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Name: 1,3-Dimethoxybenzene. Xu, C; He, Z; Yang, HQ; Chen, HY; Zeng, QL in [Xu, Chao; He, Ze; Yang, Hongqin; Chen, Hongyi; Zeng, Qingle] Chengdu Univ Technol, Coll Mat Chem & Chem Engn, State Key Lab Geohazard Prevent & Geoenvironm Pro, Chengdu 610059, Peoples R China published FeCl3-catalyzed three-component aryl-selenylation of alkenes in 2021, Cited 52. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0.

FeCl3-catalyzed three-component aryl-selenylation of alkenes with good to excellent yields has been disclosed. This method is characterized by synthesis of complicated products in a single-step reaction, simple operation and readily available commercially reagents. Finally, a reasonable mechanism of FeCl3-catalyzed aryl-selenylation is proposed. (C) 2021 Elsevier Ltd. All rights reserved.

Welcome to talk about 151-10-0, If you have any questions, you can contact Xu, C; He, Z; Yang, HQ; Chen, HY; Zeng, QL or send Email.. Name: 1,3-Dimethoxybenzene

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Product Details of 93-97-0. In 2019 CHEMISTRYSELECT published article about ENANTIOSELECTIVE ACYL TRANSFER; ACHIRAL CARBOXYLIC-ACIDS; ASYMMETRIC ESTERIFICATION; PIVALIC ANHYDRIDE; DIPHENYLACETIC ACID; LIPASE; ALCOHOLS in [Ichimura, Taiju; Kishida, Ryota; Nakata, Kenya] Shimane Univ, Grad Sch Nat Sci & Technol, Dept Chem, 1060 Nishikawatsu, Matsue, Shimane 6908504, Japan in 2019, Cited 46. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0.

Non-enzymatic acylative kinetic resolution of racemic 2,2-dimethyl-substituted nitroaldol (Henry) adducts was achieved using cyclohexanecarboxylic anhydride in the presence of chiral guanidine catalyst. The systematic evaluation of the substituents on the aromatic rings of the substrates were conducted to clarify the influence of the substituents. The reaction was smoothly proceeded with moderate to good s-values, regardless of the kinds of the substituents. Based on the absolute configuration of the resulted product, the transition state of the reaction was predicted, and it was important the interaction between the nitro group on the substrate and the cation face of the acyl-guanidium intermediate to determine the direction of the substrate.

Product Details of 93-97-0. Welcome to talk about 93-97-0, If you have any questions, you can contact Ichimura, T; Kishida, R; Nakata, K or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Name: 3-Methylbenzoic acid. In 2019 CHEM COMMUN published article about CARBOXYLIC-ACID SALTS; AEROBIC OXIDATION; CATALYTIC CONVERSION; SELECTIVE OXIDATION; WATER; METAL; ALDEHYDES; EFFICIENT; HYDROGEN; LIGANDS in [Wang, Zhi-Qin; Wang, Hua-Jing; Sang, Wei; Yuan, Ye; Chen, Cheng; Verpoort, Francis] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, 122 Luoshi Rd, Wuhan 430070, Peoples R China; [Wang, Zhi-Qin; Sang, Wei] Wuhan Univ Technol, Sch Mat Sci & Engn, 122 Luoshi Rd, Wuhan 430070, Peoples R China; [Tang, Xiao-Sheng] Chongqing Univ, Minist Educ, Key Lab Optoelect Technol & Syst, Coll Optoelect Engn, Chongqing 400044, Peoples R China; [Yang, Zhao-Qi] Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R China; [Yu, Bao-Yi] Beijing Agr Univ, Minist Agr, Key Lab Urban Agr North China, Beinong Rd 7, Beijing 102206, Peoples R China; [Verpoort, Francis] Natl Res Tomsk Polytech Univ, Lenin Ave 30, Tomsk 634050, Russia; [Verpoort, Francis] Ghent Univ Global Campus, 119 Songdomunhwa Ro, Incheon 21985, South Korea in 2019, Cited 45. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

Eight bidentate NHC/Ru complexes, namely [Ru]-1-[Ru]-8, were designed and prepared. In particular, [Ru]-2 displayed extraordinary performance even in open air for the dehydrogenative coupling of alcohols and hydroxides. Notably, an unprecedentedly low catalyst loading of 250 ppm and the highest TON of 32 800 and TOF of 3200 until now were obtained.

About 3-Methylbenzoic acid, If you have any questions, you can contact Wang, ZQ; Tang, XS; Yang, ZQ; Yu, BY; Wang, HJ; Sang, W; Yuan, Y; Chen, C; Verpoort, F or concate me.. Name: 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about ONE-POT; REGIOSELECTIVE SYNTHESIS; MANNICH PRODUCTS; FACILE SYNTHESIS; DERIVATIVES; EFFICIENT; GREEN; WATER, Saw an article supported by the SERB, New Delhi, IndiaDepartment of Science & Technology (India)Science Engineering Research Board (SERB), India [EEQ/2016/000376]; UGC, New DelhiUniversity Grants Commission, India [1-14/2002-2016(NS/PE), F-540/5/CASII/2018 (SAP-I)]; SERB, New DelhiDepartment of Science & Technology (India)Science Engineering Research Board (SERB), India. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Sharma, MG; Vala, RM; Patel, HM. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Category: isothiazole

Green synthesis of pyrazolo[3,4-b]quinolinones was designed using bioproduct pyridine-2-carboxylic acid (P2CA) as a green and efficient catalyst. The multi-component reaction of aldehydes, 1,3-cyclodiones and 5-amino-1-phenyl-pyrazoles regioselectively produced pyrazolo[3,4-b]quinolinones in excellent yield (84-98%). Recyclization of the catalyst was also investigated. The electronic effect of the various substituents in aromatic rings indicated that the reaction proceeded through the carbocation intermediate. This newly designed protocol very quickly constructed products conventionally under milder conditions.

Category: isothiazole. Welcome to talk about 93-02-7, If you have any questions, you can contact Sharma, MG; Vala, RM; Patel, HM or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com