Category: isothiazole. I found the field of Chemistry very interesting. Saw the article Continuous Flow Preparation of Enantiomerically Pure BINOL(s) by Acylative Kinetic Resolution published in 2020, Reprint Addresses Pericas, MA (corresponding author), Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Av Paisos Catalans 16, Tarragona 43007, Spain.; Pericas, MA (corresponding author), Univ Barcelona, Dept Quim Inorgan & Organ, E-08028 Barcelona, Spain.. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride.
A polystyrene-immobilized isothiourea has been applied to the enantioselective acylative kinetic resolution (KR) of monoacylated BINOL(s) with inexpensive isobutyric anhydride in batch and flow. High selectivity values (s=29 at 0 degrees C) and a remarkable stability of the catalytic system in the operation conditions have been recorded for unsubstituted BINOL. No significant loss of activity/selectivity is recorded after 10 consecutive KR cycles in batch. A continuous flow process has been implemented and operated with a 100 mmol (32.8 g) sample of racemic monoacetylated BINOL in dichloromethane solution in an 84 hours experiment with a packed bed reactor containing 1 g (f=0.37 mmol.g(-1)) of the functional resin (s=17-21). Residence time can be decreased to 10 min with the same reactor to achieve a conversion of 58% with a selectivity factor s=17 when a more highly functionalized catalyst (f=0.88 mmol.g(-1)) is used. This translates into a remarkable combined productivity of 5.5 mmol(prod) . mmol(cat)(-1) . h(-1).
Category: isothiazole. Welcome to talk about 93-97-0, If you have any questions, you can contact Lai, JS; Neyyappadath, RM; Smith, AD; Pericas, MA or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com