COA of Formula: C8H8O2. Chen, L; Quan, HT; Xu, ZL; Wang, H; Xia, YZ; Lou, LG; Yang, WB in [Chen, Lu; Quan, Haitian; Xu, Zhongliang; Wang, Hao; Lou, Liguang; Yang, Weibo] Chinese Acad Sci, Chinese Acad Sci Key Lab Receptor Res, Shanghai Inst Mat Med SIMM, Shanghai, Peoples R China; [Chen, Lu; Quan, Haitian; Xu, Zhongliang; Wang, Hao; Lou, Liguang; Yang, Weibo] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Xia, Yuanzhi] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China; [Yang, Weibo] Univ Sci & Technol Liaoning, Key Lab Funct Mat, Educ Dept Liaoning Prov, Anshan 114051, Peoples R China published A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation in 2020, Cited 30. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.
One of the key challenges to overcome multidrug resistance (MDR) in cancer is the development of more effective and general strategies to discover bioactive scaffolds. Inspired by natural products, we describe a strategy to achieve this goal by modular biomimetic synthesis of scaffolds of (Z)-allylic-supported macrolides. Herein, an Rh(III)-catalyzed native carboxylic acid-directed and solvent-free C-H activation allylation with high stereoselectivity and chemoselectivity is achieved. The generated poly-substituted allylic alcohol as a multifunctional and biomimetic building block is crucial for the synthesis of (Z)-allylic-supported macrolides. Moreover, the unique allylic-supported macrolides significantly potentiate the sensitivity of tumor cells to cytotoxic agents such as vinorelbine and doxetaxel by reversing p170-glycoprotein-mediated MDR. Our findings will inspire the evolution of synthetic chemistry and open avenues for expedient and diversified synthesis of bioactive macrocyclic molecules. One strategy to address multidrug resistance in cancer is the development of modular methods to access bioactive scaffolds. Here, the authors report a Rh(III)-catalyzed carboxylic acid-directed C(sp(2))-H allylation and apply it to the modular synthesis of (Z)-allylic macrolides which enhance antitumoral drug activity.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com