I found the field of Chemistry very interesting. Saw the article Synthesis of some 5-arylidene-2-(4-acetamidophenylimino)-thiazolidin-4-one derivatives and exploring their breast anticancer activity published in 2020.0. Recommanded Product: 2,5-Dimethoxybenzaldehyde, Reprint Addresses Abumelha, HMA (corresponding author), Princess Nourah Bint Abdulrahman Univ, Fac Sci, Dept Chem, Riyadh 84428, Saudi Arabia.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde
Ten 2-(4-acetamidophenylimino)-5-arylidenethiazolidin-4-one derivatives 6a-k were synthesized and evaluated for their anticancer activity against MCF-7 cell line (breast adenocarcinoma). The synthetic approach involves cyclocondensation of N,N ‘-bis(4-acetamidophenyl)-thiourea (3) with ethyl bromoacetate in ethanol and sodium acetate to furnish the 2-(4-acetamidophenylimino)-4-thiazolidinone derivative 4, which underwent Knoevenagel condensation reaction with some substituted aldehydes to afford the targeted 2-(4-acetamidophenylimino)-5-arylidenethiazolidin-4-ones 6a-k. The 4-chlorobenzylidene-thiazolidin-4-one compound 6h exhibited strong inhibitory effect on the growth of breast cancer cell with IC50 (58.33 +/- 1.74 mu M), very close to that of the reference drug doxorubicin (IC50 48.06 +/- 0.36 mu M).
Recommanded Product: 2,5-Dimethoxybenzaldehyde. Welcome to talk about 93-02-7, If you have any questions, you can contact Abumelha, HMA; Saeed, A or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com