In 2019 J ENZYM INHIB MED CH published article about ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; INHIBITORS; BINDING; HYBRIDS in [Hu, Yu-Heng; Yang, Jie; Liu, Teng; Sun, Jie; Wang, Xiao-Jing] Univ Jinan, Shandong Acad Med Sci, Sch Med & Life Sci, Jinan 250200, Shandong, Peoples R China; [Hu, Yu-Heng; Yang, Jie; Liu, Teng; Sun, Jie; Wang, Xiao-Jing] Shandong Acad Med Sci, Inst Mat Med, Jinan, Shandong, Peoples R China; [Hu, Yu-Heng; Yang, Jie; Liu, Teng; Sun, Jie; Wang, Xiao-Jing] Minist Hlth, Key Lab Biotech Drugs, Jinan, Shandong, Peoples R China; [Hu, Yu-Heng; Yang, Jie; Liu, Teng; Sun, Jie; Wang, Xiao-Jing] Key Lab Rare & Uncommon Dis Shandong Prov, Jinan, Shandong, Peoples R China; [Zhang, Yun; Liu, Ke-Chun] Qilu Univ Technol, Shandong Acad Sci, Biol Inst, Jinan, Shandong, Peoples R China in 2019, Cited 28. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Computed Properties of C8H8O2
The work is focused on the design of drugs that prevent and treat Alzheimer’s disease (AD) and its complications. A series of 3-(4-aminophenyl)-coumarin derivatives designed, synthesised, fully characterised and evaluated in vitro/vivo. The biological assay experiments showed that some compounds displayed a clearly selective inhibition for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among all compounds, compound 4m exhibited the highest AChE inhibition with an IC50 value of 0.091 +/- 0.011 mu M and compound 4k exhibited the highest BuChE inhibition with an IC50 value of 0.559 +/- 0.017 mu M. A zebrafish behaviour analyser (Zebrobox) was used to determine the behavioural effects of the active compound on the movement distance of the aluminium chloride-induced zebrafish. Compound 4m offered a potential drug design concept for the development of therapeutic or preventive agents for AD and its complications.
Welcome to talk about 99-04-7, If you have any questions, you can contact Hu, YH; Yang, J; Zhang, Y; Liu, KC; Liu, T; Sun, J; Wang, XJ or send Email.. Computed Properties of C8H8O2
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com