An article Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides WOS:000567135300001 published article about DERIVATIVES; DESIGN in [Zhao, Shengxian; Zhang, Jiayun; Pan, Zhixiang; Hu, Hongyu] Ningbo Univ, Coll Sci & Technol, Cixi 315302, Peoples R China; [Cao, Yin; Cui, Zhenzhen] Xiamen Univ, Sch Pharmaceut Sci, South Xiang An Rd, Xiamen 361102, Peoples R China; [Cao, Yin; Cui, Zhenzhen] Xiamen Univ, Key Lab Chem Biol Fujian Prov, South Xiang An Rd, Xiamen 361102, Peoples R China; [Hu, Hongyu] Zhejiang Normal Univ, Xingzhi Coll, Lanxi 321100, Peoples R China in 2020.0, Cited 21.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. COA of Formula: C9H10O3
A series of 2-arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides 5a-5o were synthesized and characterized. The synthesized compounds (5a-5o) were screenedin vitro against three breast cancer cell lines: SKBR3, MDA-MB-231, and MCF-7 cancer cell lines by the MTT assay. According to MTT results, compounds 5k and 5l showed better antiproliferative activities over MCF-7 cell lines with IC50 values of 8.50 and 12.51 mu M. Colony formation assay indicated 5k/5l treatment obviously inhibited the growth of MCF-7 cells and 5k/5l-induced cell cycle was arrested in the G2-M phase. Moreover, 5k/5l significantly increased the level of cleaved PARP and induced the apoptosis in MCF-7 cells. In addition, compared to Hela cells, MCF-7 cells were more sensitive to 5k/5l treatment.
Welcome to talk about 93-02-7, If you have any questions, you can contact Zhao, SX; Cao, Y; Cui, ZZ; Zhang, JY; Pan, ZX; Hu, HY or send Email.. COA of Formula: C9H10O3
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com