In 2019.0 ORG LETT published article about SOLUTION-PHASE PREPARATION; PICTET-SPENGLER REACTION; ASYMMETRIC-SYNTHESIS; BOBBITT SYNTHESIS; UGI; ALKALOIDS; EFFICIENT; MCR; FUNCTIONALIZATION; QUINOLINES in [Wang, Yuanze; Patil, Pravin; Domling, Alexander] Univ Groningen, Drug Design, Deusinglaan 1, NL-7313 AV Groningen, Netherlands; [Kurpiewska, Katarzyna; Kalinowska-Tluscik, Justyna] Jagiellonian Univ, Fac Chem, 3 Ingardena St, PL-30060 Krakow, Poland in 2019.0, Cited 74.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Recommanded Product: 93-02-7
The Pomeranz-Fritsch reaction and its Schlittler-Muller modification were successfully applied in the Ugi postcyclization strategy by using orthogonally protected aminoacetaldehyde diethyl acetal and complementary electron rich building blocks. Several scaffolds, including isoquinolines, carboline, alkaloid-like tetrazole-fused tetracyclic compounds, and benzo[d]azepinone scaffolds, were synthesized in generally moderate to good yield. All our syntheses provide a short MCR-based sequence to novel or otherwise difficult to access scaffolds. Hence, we foresee multiple applications of these synthesis technologies.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com