I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy very interesting. Saw the article Anticancer potential of some imidazole and fused imidazole derivatives: exploring the mechanism via epidermal growth factor receptor (EGFR) inhibition published in 2020.0. Application In Synthesis of 2,5-Dimethoxybenzaldehyde, Reprint Addresses Singh, S; Munshi, A (corresponding author), Cent Univ Punjab, Dept Human Genet & Mol Med, Sch Hlth Sci, Bathinda 151001, India.; Kumar, R (corresponding author), Cent Univ Punjab, Dept Pharmaceut Sci & Nat Prod, Sch Basic & Appl Sci, Bathinda 151001, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde
Imidazole-based epidermal growth factor receptor (EGFR) inhibitors were computationally designed and synthesized. All the compounds were assessed for their anti-proliferative activity against five cancer cell lines,viz., MDA-MB-231 (breast), T47D (breast) and MCF-7 (breast), A549 (lung) and HT-29 (colorectal). Compounds2cand2demerged as better anticancer molecules with no toxicity towards normal cells.2cand2dinhibited EGFR enzymatic activityin vitrowith IC(50)values of 617.33 +/- 0.04 nM and 710 +/- 0.05 nM, respectively. In order to further improve the potency, we explored an unoccupied area of the ATP binding domain of EGFR and analysed anin silicointeraction model of2cand2d-EGFR complexes that guided and allowed substitution of the 4-fluorophenyl ring (2cand2d) with 4-(4-methylpiperazinyl)-3-nitrophenyl at the N-9 position, resulting in compound3cwith a better binding score and potent EGFR inhibitory activity (IC50: 236.38 +/- 0.04 nM), which was comparable to the positive control erlotinib (239.91 +/- 0.05 nM).3cexhibited a great improvement in anticancer potency with inhibition of cell growth of all cancer cell lines at very low micromolar concentrations (IC50= 1.98 to 4.07 mu M). Further investigation revealed that3calso induced an increase in ROS levels in cancer cells in a mitochondrial-independent manner and halted the cell cycle at the sub-G(1)phase.
Application In Synthesis of 2,5-Dimethoxybenzaldehyde. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com