Recently I am researching about FACILE SYNTHESIS; DERIVATIVES; 1,3,4-THIADIAZOLE; ANTICANCER, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21262012]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2016CFB400]. Published in CHINESE JOURNAL STRUCTURAL CHEMISTRY in FUJIAN ,Authors: Song, XJ; Wang, XM; Sun, Q; Huang, ST; Wang, Y. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid. HPLC of Formula: C8H8O2
N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N’-((E)-styryl)ureas 4a similar to 4i were designed and synthesized as antitumor agents, and their structures were characterized by IR, H-1 NMR, C-13 NMR, MS and elemental analysis. The single crystal of compound 4a, C17H13FN4OS, was also determined by X-ray crystallography. Crystal data: monoclinic, space group P21/n, a = 4.9401(8), b = 8.7100(15), c = 36.604(6) angstrom, beta = 93.320(3)degrees, V = 1572.4(5) angstrom(3), Z = 4, F(000) = 704, D-c = 1.438 g/cm(3), mu = 0.228 mm(-1), R = 0.0600 and wR = 0.1448 for 2743 independent reflections (R-int = 0.0418) and 2174 observed ones (I > 2 sigma(I)). The in vitro antitumor activities of compounds 4a similar to 4i were preliminarily evaluated by the standard MTT assay.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com