An article Asymmetric synthesis of ABC tricyclic systems in Daphniphyllum alkaloid WOS:000527915100014 published article about A-TYPE ALKALOIDS; OXIDATIVE CYCLIZATION; RING-SYSTEM; RAPID CONSTRUCTION; TETRACYCLIC CORE; CALYCIPHYLLINE; SKELETON; CHEMISTRY in [Wang, Huijing; Tang, Pei] Sichuan Univ, Sichuan Engn Lab Plant Sourced Drug, Educ Minist, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China; [Wang, Huijing; Tang, Pei] Sichuan Univ, West China Sch Pharm, Sichuan Res Ctr Drug Precis Ind Technol, Chengdu 610041, Peoples R China; [Dong, Qiuyan; Xie, Qinxia] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Product Synth & Drug Res, Chongqing 401331, Peoples R China; [Wang, Huijing] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA in 2020, Cited 48. Product Details of 93-97-0. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0
Efficient synthetic routs for the direct and rapid construction of [5-6-6] ABC tricyclic systems of daphmanidin A-type and calyciphylline A-type alkaloids have been successfully developed. For the daphmanidin A-type, the synthesis of [5-6-6] tricyclic framework utilize a HCl-mediated intramolecular Aldol reaction to construct the bicyclo[2.2.2]octane core and a thermal condensation to afford the ABC ring system. In addition, for the calyciphylline A-type, an improved synthesis of ABC [5-6-6] tricyclic system was developed, featuring an introduction of methyl ester group at C2 before the Pd-catalyzed intramolecular oxidative alkylation to construct the desired bowl-shape tricyclic core with stereochemical control. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com