Product Details of 93-02-7. Recently I am researching about FUNCTIONAL SELECTIVITY; REPERFUSION INJURY; RESOLUTION; TARGET, Saw an article supported by the National Health and Medical Research Council (NHMRC) of AustraliaNational Health and Medical Research Council of Australia [APP1045140, APP1120853]; National Health and Medical Research Council of Australia (NHMRC)National Health and Medical Research Council of Australia [APP1020411, APP1117602, APP1059960]; NHMRCNational Health and Medical Research Council of Australia [APP1145769]; Australian Government’s National Collaborative Research Infrastructure Strategy (NCRIS) program via Therapeutic Innovation Australia (TIA). Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Deora, GS; Qin, CX; Vecchio, EA; Debono, AJ; Priebbenow, DL; Brady, RM; Beveridge, J; Teguh, SC; Deo, M; May, LT; Krippner, G; Ritchie, RH; Baell, JB. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde
Herein we describe the development of a focused series of functionalized pyridazin-3(2H)-one-based formyl peptide receptor (FPR) agonists that demonstrate high potency and biased agonism. The compounds described demonstrated biased activation of prosurvival signaling, ERK1/2 phosphorylation, through diminution of the detrimental FPR1/2-mediated intracellular calcium (Ca-i(2+)) mobilization. Compound 50 showed an EC50 of 0.083 mu M for phosphorylation of ERK1/2 and an approximate 20-fold bias away from Ca-i(2+) mobilization at the hFPR1.
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