I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis and evaluation of the HIF-1 alpha inhibitory activities of novel ursolic acid tetrazole derivatives published in 2019. SDS of cas: 93-97-0, Reprint Addresses Jin, XJ; Piao, HR (corresponding author), Yanbian Univ, Key Lab Nat Resources Changbai Mt & Funct Mol, Minist Educ, Coll Pharm, Yanji 133002, Peoples R China.. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride
The hypoxia-inducible factor-la (HIF-1 alpha) pathway has been implicated in tumor angiogenesis, growth, and metastasis. Therefore, the inhibition of this pathway is an important therapeutic target for the treatment of various types of cancers. Here, we designed and synthesized 31 ursolic acid (UA) derivatives containing a tetrazole moiety and evaluated them for their potential anti-tumor activities as HIF-la transcriptional inhibitors. Of these, compound 14d (IC50 0.8 +/- 0.2 mu M) displayed the most potent activity and compounds 14a (IC50 4.7 +/- 0.2 mu M) exhibited the most promising biological profile. Analysis of the structure-activity relationships of these compounds with HIF-1 alpha suggested that the presence of a tetrazole group located at C-28 of the UA derivatives was critical for their inhibitory activities.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com