Day: December 24, 2021

Dissanayake, DMMM; Melville, AD; Vannucci, AK in [Dissanayake, D. M. M. Mevan; Melville, Alex D.; Vannucci, Aaron K.] Univ South Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA published Electrochemical anion pool synthesis of amides with concurrent benzyl ester synthesis Electronic supplementary information (ESI) available. See DOI: 10.1039/C9GC00707E in 2019, Cited 33. Recommanded Product: 93-97-0. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0.

An electrosynthesis method for amide bond formation has been developed in an attempt to increase the atom economy for this class of reactions. This anion pool method electrochemically generates strong nucleophiles from amine substrates. The amine nucleophiles then react with acid anhydrides to generate amides, and the by- product from this reaction undergoes further chemical transformations to generate pharmaceutically relevant benzoic esters. These one- pot reactions are operationally simple, are performed at room temperature, and avoid rare transition metals and added bases. The amide synthesis is amenable to primary and secondary amines and a variety of anhydrides with yields up to 90% obtained. Atom economy and process mass index ( PMI) values calculated for this procedure indicate that this process can be considered greener compared to traditional amide synthesis routes used by industry. Furthermore, this electrochemical approach showed unique selectivity when substrates that contained two inequivalent amine moieties were examined.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Quality Control of 2,6-Difluorobenzoic acid. I found the field of Chemistry very interesting. Saw the article Palladium-catalyzed Decarboxylative alpha-Polyfluoroarylation of Ketones published in 2021, Reprint Addresses Doi, R; Sato, Y (corresponding author), Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan.. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid.

Herein, we report palladium-catalyzed decarboxylative alpha-polyfluoroarylation of ketones. As a result of reaction condition screening, XPhos and Ruphos were selected as ancillary ligands for Pd(0) catalysts. The reaction was applied to a variety of substrates. A cross-over experiment was conducted to gain insight into the reaction mechanism.

Quality Control of 2,6-Difluorobenzoic acid. Bye, fridends, I hope you can learn more about C7H4F2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Design, synthesis, and anticancer evaluation of benzophenone derivatives bearing naphthalene moiety as novel tubulin polymerization inhibitors WOS:000592527300006 published article about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; IN-VITRO; BINDING; AGENTS; MICROTUBULES; PHENSTATIN in [Wang, Guangcheng; Gong, Zipeng; Huang, Yong] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guizhou Prov Key Lab Pharmaceut, Guiyang, Peoples R China; [Wang, Guangcheng] Jishou Univ, Coll Chem & Chem Engn, Jishou, Peoples R China; [Peng, Zhiyun] Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai, Peoples R China; [Liu, Wenjing; Ma, Xue; Li, Yongjun] Guizhou Med Univ, Minist Educ, Engn Res Ctr Dev & Applicat Ethn Med & TCM, Guiyang, Peoples R China; [Liu, Wenjing] Guizhou Med Univ, Sch Pharm, Guiyang, Peoples R China; [Tang, Juan] Guizhou Med Univ, Affiliated Hosp, Guiyang, Peoples R China in 2020, Cited 32. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. COA of Formula: C8H8O2

A series of benzophenone derivatives bearing naphthalene moiety were designed, synthesized, characterized by H-1 NMR, C-13 NMR, and HRMS and evaluated for their antiproliferative activity against human breast cancer cell line (MCF-7). Most of the tested derivatives showed good to moderate cytotoxicity against MCF-7 cell line. Among them, compound 4u (IC50 = 1.47 +/- 0.14 mu M) was found to be the most active compound, which is more active than the standard drug cisplatin (IC50 = 15.24 +/- 1.27 mu M). In vitro tubulin polymerization in-hibition assay, EBI competition assay, cell cycle analysis, and cell apoptosis assay identified that compound 4u was a new tubulin polymerization inhibitor by targeting the colchicine binding site. Besides, molecular docking study showed that compound 4u has high binding affinities with the colchicine binding site of tubulin through hydrogen bond, cation-pi, and hydrophobic interaction.

COA of Formula: C8H8O2. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Nickel-Catalyzed Selective Reduction of Carboxylic Acids to Aldehydes WOS:000489200100026 published article about DIRECT HYDROGENATION; DIRECT CONVERSION; ALKYL-HALIDES; HYDROSILYLATION; HYDRIDE; KETONES; ANHYDRIDES; BASE; MILD; DISCOVERY in [Iosub, Andrei, V; Moravcik, Stefan; Bergman, Joakim] AstraZeneca, BioPharmaceut R&D, Med Chem Res & Early Dev Cardiovasc, Renal & Metab, Gothenburg, Sweden; [Wallentin, Carl-Johan] Gothenburg Univ, Dept Chem & Mol Biol, Gothenburg, Sweden in 2019, Cited 66. SDS of cas: 93-97-0. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0

The direct reduction of carboxylic acids to aldehydes is a fundamental transformation in organic synthesis. The combination of an air-stable Ni precatalyst, dimethyl dicarbonate as an activator, and silane reductant effects this reduction for a wide variety of substrates, including pharmaceutically relevant structures, in good yields and with no overreduction to alcohols. Moreover, this methodology is scalable, allows access to deuterated aldehydes, and is also compatible with one-pot utilization of the aldehyde products.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Exploration of New Biomass-Derived Solvents: Application to Carboxylation Reactions WOS:000512479000001 published article about COPPER-CATALYZED CARBOXYLATION; LIFE-CYCLE ASSESSMENT; CARBON-DIOXIDE; REGIOSELECTIVE HYDROCARBOXYLATION; ALKYLATIVE CARBOXYLATION; VISIBLE-LIGHT; CO2; ALKYNES; ALKENES; ESTERS in [Gevorgyan, Ashot; Bayer, Annette] UiT Arctic Univ Norway, Dept Chem, N-9037 Tromso, Norway; [Hopmann, Kathrin H.] UiT Arctic Univ Norway, Dept Chem, Hylleraas Ctr Quantum Mol Sci, N-9037 Tromso, Norway in 2020, Cited 109. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. COA of Formula: C8H8O2

A range of hitherto unexplored biomass-derived chemicals have been evaluated as new sustainable solvents for a large variety of CO2-based carboxylation reactions. Known biomass-derived solvents (biosolvents) are also included in the study and the results are compared with commonly used solvents for the reactions. Biosolvents can be efficiently applied in a variety of carboxylation reactions, such as Cu-catalyzed carboxylation of organoboranes and organoboronates, metal-catalyzed hydrocarboxylation, borocarboxylation, and other related reactions. For many of these reactions, the use of biosolvents provides comparable or better yields than the commonly used solvents. The best biosolvents identified are the so far unexplored candidates isosorbide dimethyl ether, acetaldehyde diethyl acetal, rose oxide, and eucalyptol, alongside the known biosolvent 2-methyltetrahydrofuran. This strategy was used for the synthesis of the commercial drugs Fenoprofen and Flurbiprofen.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Category: isothiazole. Recently I am researching about QUANTUM DOTS; PHOTOREDOX CATALYSIS; GRAPHENE OXIDE; NANODOTS, Saw an article supported by the IIT Indore; MHRD, New Delhi. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Sarma, D; Majumdar, B; Sarma, TK. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene

The development of carbonaceous materials as metal-free catalysts integrating different types of catalysis in a single system represents a significant advance in cascade/tandem organic synthesis. Zero-dimensional carbon dots with tuneable optical properties and easily modifiable surface functionalities can be harnessed as a carbocatalyst for merging photooxidation and acid-catalyzed reactions in one pot. Herein, we explore carbon dots decorated with hydrogen sulfate groups as a photocatalyst for the dehydrogenative cross-coupling of xanthenes with ketones, arenes and 1,3-dicarbonyl compounds that showed high efficiency and selectivity under visible-light irradiation. The sulphated carbon dots demonstrate dual catalytic properties, wherein they induced the rapid photooxidation of xanthenes in the presence of molecular oxygen to form a hydroperoxy intermediate followed by coupling of nucleophiles catalysed by the acidic surface functional groups. The methodology represents an operationally simple pathway for the generation of C-C coupling products in a short reaction time with wide substrate scopes under mild conditions. The catalyst is easily separable and can be reused over multiple cycles with good efficiency.

Category: isothiazole. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Sarma, D; Majumdar, B; Sarma, TK or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recommanded Product: 93-02-7. I found the field of Chemistry very interesting. Saw the article An Efficient and Transition Metal-Free Base-Promoted Multi-Component Synthesis of Aza-Fused Polysubstituted Pyrido[2 ‘,3 ‘:3,4]Pyrazolo[1,5-a]Pyrimidine Derivatives published in 2020.0, Reprint Addresses Jeong, YT (corresponding author), Pukyong Natl Univ, Dept Image Sci & Engn, Busan 608737, South Korea.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde.

An efficient and concise practical protocol for the synthesis of novel aza-fused polysubstituted pyrido[2 ‘,3 ‘:3,4]pyrazolo[1,5-a]pyrimidine derivatives from a readily available aromatic aldehyde, acetophenone and 1H-pyrazolo[3,4-b]pyridin-3-amine in presence of Ba(OH)(2), under transition metal-free conditions, has been established. This transformation presumably occurs through a sequential Aldol reaction, imine-formation, intramolecularN-cyclization, auto-oxidation sequence of reactions. This protocol, which includes the formation of new C-C and C-N bonds, features a wide substrate scope with a broad range of functional group tolerance.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recommanded Product: 93-02-7. Recently I am researching about ANTIPROLIFERATIVE ACTIVITY; SESAME SEED; IN-VITRO; LIGNANS; INHIBITORS; OXIDATION; ARYLATION; DISCOVERY; BENZENE; KINASE, Saw an article supported by the CSIR, New DelhiCouncil of Scientific & Industrial Research (CSIR) – India; UGCUniversity Grants Commission, India; Department of Science and Technology DSTDepartment of Science & Technology (India); DSTDepartment of Science & Technology (India) [EMR/2014/000013]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Mane, KD; Mukherjee, A; Vanka, K; Suryavanshi, G. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

A highly regioselective, efficient, and metal-free oxidative cross dehydrogenative coupling (CDC) of aryl carbonyls with cyclic ethers has been developed. This method offers easy access to substituted alpha-arylated cyclic ethers with a high functional group tolerance in good to excellent yields. The regioselectivity of this CDC reaction was confirmed by density functional theory (DFT)-based calculations.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Nasseri, MA; Kazemnejadi, M; Mahmoudi, B; Assadzadeh, F; Alavi, SA; Allahresani, A in SPRINGER published article about ONE-POT SYNTHESIS; ACIDIC IONIC LIQUID; REUSABLE CATALYST; N-BUTANE; COMPLEX; OXIDE; ZRO2; EPOXIDATION; XANTHENES; OLEFINS in [Nasseri, Mohammad Ali; Kazemnejadi, Milad; Assadzadeh, Fahimeh; Alavi, Seyyedeh Ameneh; Allahresani, Ali] Univ Birjand, Fac Sci, Dept Chem, POB 97175-615, Birjand, Iran; [Mahmoudi, Boshra] Cihan Univ Sulaimani, Med Lab Dept, Sulaimani 46001, Kurdistan Regio, Iraq; [Mahmoudi, Boshra] Sulaimani Polytech Univ, Res Ctr, Sulaimani 46001, Kurdistan Regio, Iraq in 2019.0, Cited 67.0. SDS of cas: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

This study presents one-pot multicomponent preparation of 1,8-dioxo-octahydroxanthene derivatives under very mild conditions using cobalt-incorporated sulfated zirconia (ZrO2/SO42-/Co) as an efficient heterogeneous recyclable multifunctional nanocatalyst. The nanocatalyst was successfully characterized by FTIR, XRD, TGA, FE-SEM, TEM, ICP, and EDX analyses. The nanoparticles have a mean size of 13 nm, with a combination of the monoclinic-tetragonal crystal structure. A wide scope of aldehydes bearing different functional groups was condensed with dimedone and/or 1,3-cyclohexadione in water at room temperature with good-to-high yields at short reaction times. The catalyst can be efficiently recovered and reused several times without much loss of its activity. Besides, hot filtration test gives more insight into the heterogeneous nature of the catalyst. Finally, a plausible mechanism for this transformation was proposed. Graphical abstract A facile and convenient method for the synthesis of 1,8-dioxo-octahydroxanthenes has been developed using cobalt-incorporated sulfated zirconia as an efficient recyclable nanocatalyst.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Dashteh, M; Baghery, S; Zolfigol, MA; Bayat, Y; Asgari, A in WILEY-V C H VERLAG GMBH published article about ONE-POT SYNTHESIS; 1-METHYLIMIDAZOLIUM TRICYANOMETHANIDE; EFFICIENT CATALYST; REACTION MEDIA; DERIVATIVES; GREEN; LIQUID; 4,4′-(ARYLMETHYLENE)BIS(1H-PYRAZOL-5-OL); SOLVENT; ACETATE in [Dashteh, Mohammad; Baghery, Saeed; Zolfigol, Mohammad Ali] Bu Ali Sina Univ, Fac Chem, Dept Organ Chem, Hamadan 6517838683, Iran; [Bayat, Yadollah; Asgari, Asiye] Malek Ashtar Univ Technol, Fac Chem & Chem Engn, Tehran, Iran in 2019.0, Cited 57.0. Recommanded Product: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

1,10-Phenanthrolin-1-ium trinitromethanide (1,10-PHTNM) as a novel nano molten slat with Y-aromatic counter ion was synthesized and fully characterized by using various techniques such as FT-IR, H-1 NMR, C-13 NMR, mass, TGA, DTG, XRD, SEM and TEM. A series of organic compounds include 1,4-dihydropyrano[2,3-c]pyrazoles, tetrahydrobenzo[b]pyran, pyrano[4,3-b]pyrans, bispyrazole, 1H-pyrazolo[3,4-b]quinolones, hexahydroacridine-1,8-diones and methylenebis(3-hydroxy-5,5-dimethylcyclohex-2-enones) were synthesized in the presence of 1,10-PHTNM as a novel and efficient proton sponge nano molten slat catalyst. According to the results of FT-IR, H-1 NMR, C-13 NMR, mass spectrum of 1,10-PHTNM and due to high electron charge density and none bonded repulsion of lone pair electrons between two nitrogen atoms (peri-effect), this catalyst is a type of proton sponge.

Recommanded Product: 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Dashteh, M; Baghery, S; Zolfigol, MA; Bayat, Y; Asgari, A or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com