In 2021.0 EUR J MED CHEM published article about MANNICH-BASES; DRUG DESIGN; HCA II; IX; XII; SULFONAMIDES; CYTOTOXICITY; METASTASIS; EXPRESSION; HYDRAZONES in [Yamali, Cem; Gul, Halise Inci] Ataturk Univ, Fac Pharm, Dept Pharmaceut Chem, Erzurum, Turkey; [Yamali, Cem] Cukurova Univ, Fac Pharm, Dept Basic Pharmaceut Sci, Adana, Turkey; [Sakagami, Hiroshi] Meikai Univ, Res Inst Odontol M RIO, Saitama, Japan; [Uesawa, Yoshihiro; Kurosaki, Kota] Meiji Pharmaceut Univ, Dept Med Mol Informat, Tokyo, Japan; [Satoh, Keitaro] Meikai Univ, Div Pharmacol, Sch Dent, Saitama, Japan; [Masuda, Yoshiko] Matsumoto Dent Univ, Dept Operat Dent, Nagano, Japan; [Yokose, Satoshi] Meikai Univ, Div Endodont & Operat Dent, Sch Dent, Sakado, Saitama, Japan; [Ece, Abdulilah] Biruni Univ, Fac Pharm, Dept Pharmaceut Chem, Istanbul, Turkey; [Bua, Silvia; Angeli, Andrea; Supuran, Claudiu T.] Univ Firenze, Neurofarba Dept, Sez Sci Farmaceut & Nutraceut, Via U Schiff 6, I-50019 Florence, Italy in 2021.0, Cited 54.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. SDS of cas: 93-02-7
In this research, rational design, synthesis, carbonic anhydrases (CAs) inhibitory effects, and cytotoxicities of the 4-(3-(2-arylidenehydrazine-1-carbonyl)-5-(thiophen-2-yl)-1H-pyrazole-1-yl)benzenesulfonamides 1-20 were reported. Compound 18 (Ki = 7.0 nM) was approximately 127 times more selective cancer-associated hCA IX inhibitor over hCA I, while compound 17 (Ki = 10.6 nM) was 47 times more selective inhibitor of hCA XI over hCA II compared to the acetazolamide. Compounds 11 (CC50 = 5.2 mM) and 20 (CC50 = 1.6 mM) showed comparative tumor-specificity (TS= > 38.5; >128.2) with doxorubicin (TS > 43.0) towards HSC-2 cancer cell line. Western blot analysis demonstrated that 11 induced slightly apoptosis whereas 20 did not induce detectable apoptosis. A preliminary analysis showed that some correlation of tumor-specificity of 1-20 with the chemical descriptors that reflect hydrophobic volume, dipole moment, lowest hydrophilic energy, and topological structure. Molecular docking simulations were applied to the synthesized ligands to elucidate the predicted binding mode and selectivity profiles towards hCA I, hCA II, and hCA IX. (C) 2021 Elsevier Masson SAS. All rights reserved.
Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 93-02-7
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com