Formula: C8H8O2. Luo, SS; Xu, ST; Liu, JK; Ma, FF; Zhu, YZ in [Luo, Shanshan] Nanjing Med Univ, Key Lab Cardiovasc & Cerebrovasc Med, 101 Longmian Ave, Nanjing 211166, Peoples R China; [Xu, Shengtao; Liu, Junkai] China Pharmaceut Univ, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Peoples R China; [Xu, Shengtao; Liu, Junkai] China Pharmaceut Univ, Dept Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Peoples R China; [Ma, Fenfen] Fudan Univ, Shanghai Pudong Hosp, Dept Pharm, Shanghai 201399, Peoples R China; [Luo, Shanshan; Zhu, Yi Zhun] Macau Univ Sci & Technol, Pharm, Taipa, Macao, Peoples R China; [Luo, Shanshan; Zhu, Yi Zhun] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China; [Luo, Shanshan; Zhu, Yi Zhun] Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai 200032, Peoples R China published Design and synthesis of novel SCM-198 analogs as cardioprotective agents: Structure-activity relationship studies and biological evaluations in 2020.0, Cited 31.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.
SCM-198 (Leonurine) has attracted great attention due to its cardioprotective effects in myocardial infarction (MI). However, no systematic modifications and structure-activity relationship (SAR) studies could be traced so far. In this study, 35 analogs of SCM-198 were designed, synthesized and their cardioprotective effects were evaluated. The cell viability assay on cardiomyocyte cell line H9c2 challenged with H2O2 showed that several analogs exhibited more potent cytoprotective effects than SCM-198 at 1 mu M and 10 mu M concentrations. LDH release level in cells treated with 1 mu M 14o was comparable with cells treated with 10 mu M SCM-198. Results of Bcl-2 expression and caspase-3 activation accordingly indicated higher protective activity of 14o than SCM-198. Moreover, in a mouse model of MI, the mice pretreated with 14o had much lower infarct size compared with that of SCM-198. The mechanism study suggested that 14o improved cardiac morphology and reduced apoptosis of cardiomyocytes in the border zone of infarction, as proved by H&E and TUNEL staining. (C) 2020 Elsevier Masson SAS. All rights reserved.
Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. Formula: C8H8O2
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com