Category: isothiazole. Yuan, SJ; Zhang, YY; Liu, JX; Zhao, Y; Tan, LB; Liu, JW; Wang, QY; Zhang, H in [Yuan, Sujing; Zhang, Yunyue; Liu, Jingwen; Wang, Qingyu; Zhang, Hao] China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China; [Zhang, Yunyue; Liu, Jingwen; Wang, Qingyu; Zhang, Hao] China Agr Univ, Beijing Lab Food Qual & Safety, Beijing 100083, Peoples R China; [Liu, Jiaxin] Univ Illinois, Dept Stat, Urbana, IL 61801 USA; [Zhao, Yu] Penn State Univ, Dept Food Sci, University Pk, PA 16802 USA; [Tan, Libo] Univ Alabama, Dept Human Nutr & Hosp Management, Tuscaloosa, AL 35487 USA published Structure-affinity relationship of the binding of phenolic acids and their derivatives to bovine serum albumin in 2019, Cited 32. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.
Phenolic acids perform biological effects which are largely influenced by their binding to serum albumin. Therefore, investigating structure-affinity relationship of binding between phenolic acids and serum albumin is important. In this study, 114 phenolic acids and their derivatives, sharing the benzoic acid core with different substituents groups, were selected to investigate structure-affinity relationships with bovine serum albumin. The binding constants were obtained through fluorescence quenching, and a comprehensive mathematical model with inner-filter effect correction was applied. The results showed that the hydroxy group at the 2-position led to stronger binding affinity, while it had a negative influence at the 4-position. Substituting hydroxy groups with methoxy groups at 4-position and with methyl groups at 3-position both strengthened the binding affinity, respectively. Hydrogen bonding was one of the key binding forces for this binding interaction. Our findings provide a fundamental insight on the binding mechanism of phenolic acids to bovine serum albumin.
Category: isothiazole. Welcome to talk about 99-04-7, If you have any questions, you can contact Yuan, SJ; Zhang, YY; Liu, JX; Zhao, Y; Tan, LB; Liu, JW; Wang, QY; Zhang, H or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com