In 2019.0 ARAB J CHEM published article about CYSTEINE PROTEASE INHIBITORS; PLASMODIUM-FALCIPARUM; ACCURATE DOCKING; IDENTIFICATION; PEPTIDOMIMETICS; SUBSTRATE; MALARIA; CRUZAIN; POTENT; AGENTS in [Mahesh, Radhakrishnan; Mundra, Sourabh; Devadoss, Thangaraj] Birla Inst Technol & Sci, Dept Pharm, FD 3, Pilani 333031, Rajasthan, India; [Kotra, Lakshmi P.] Univ Hlth Network, Ctr Mol Design & Preformulat, Toronto, ON, Canada in 2019.0, Cited 43.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. SDS of cas: 99-04-7
The cysteine protease, falcipain-2 is an important drug target in human malaria parasite Plasmodium falciparum. A new series of 2-(4-(substituted benzoyl)-1,4-diazepan-1-yl)-N-phenylacetamide derivatives 5(a-t) were designed as per pharmacophoric requirements of falcipain-2 inhibitors using ligand-based approach. The target compounds were synthesized from the key intermediate, 2-(1,4-Diazepan-1-yl)-N-phenylacetamide, by coupling it with appropriate carboxylic acids using carbodiimide chemistry. Structural features of target compounds were characterized by spectral data (H-1 NMR, and mass) and elemental analyses. The purity of the final compounds was confirmed by HPLC. The compounds were tested for their in vitro falcipain-2 inhibitor activity on recombinant falcipain-2 enzyme. Five compounds 5b, 5g, 5h, 5j, 5k showed good inhibitory activity (>60%), against falcipain-2 at 10 mu M concentration, and fifteen compounds showed weak to moderate inhibitor activity. Compound 5g, the most potent compound from this series showed 72% inhibition at 10 mu M concentrations. (C) 2014 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
SDS of cas: 99-04-7. Welcome to talk about 99-04-7, If you have any questions, you can contact Mahesh, R; Mundra, S; Devadoss, T; Kotra, LP or send Email.
Reference:
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