Recommanded Product: 1,3-Dimethoxybenzene. Authors Hong, CM; Xu, YJ; Chung, JYL; Schultz, DM; Weisel, M; Varsolona, RJ; Zhong, YL; Purohit, AK; He, CQ; Gauthier, DR; Humphrey, GR; Maloney, KM; Levesque, F; Wang, ZX; Whittaker, AM; Sirota, E; McMullen, JP in AMER CHEMICAL SOC published article about in [Hong, Cynthia M.; Xu, Yingju; Chung, John Y. L.; Schultz, Danielle M.; Weisel, Mark; Varsolona, Richard J.; Zhong, Yong-Li; Purohit, Akasha K.; He, Cyndi Q.; Gauthier, Donald R., Jr.; Humphrey, Guy R.; Maloney, Kevin M.; Levesque, Francois; Wang, Zhixun; Whittaker, Aaron M.; Sirota, Eric; McMullen, Jonathan P.] Merck & Co Inc, Proc Res & Dev, Rahway, NJ 07065 USA in 2021, Cited 51. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0
We report the practical synthesis of a key fragment of islatravir (MK-8591), a novel nucleoside reverse transcriptase translocation inhibitor (NRTTI) currently under investigation for treatment and pre-exposure prophylaxis (PrEP) against HIV infection. The fragment, the unnatural nucleobase 2-fluoroadenine, is incorporated into MK-8591 via a biocatalytic aldolglycosylation cascade, which imposes stringent requirements for its synthesis and isolation. Presented herein is the development work leading to a practical, scalable route from guanine, featuring a dual fluorination approach to a novel 9-THP-2,6-difluoropurine intermediate that enables a mild, highly selective, direct amination. This one-pot fluorination/amination sequence utilizes a direct isolation to deliver high purity 9-THP-2-fluoroadenine, which features ideal properties with respect to reactivity, solubility, and crystallinity. An acid-catalyzed liberation of 2-fluoroadenine in aqueous buffer delivers the appropriate purity profile to facilitate the enzymatic cascade to access MK-8591.
Recommanded Product: 1,3-Dimethoxybenzene. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Hong, CM; Xu, YJ; Chung, JYL; Schultz, DM; Weisel, M; Varsolona, RJ; Zhong, YL; Purohit, AK; He, CQ; Gauthier, DR; Humphrey, GR; Maloney, KM; Levesque, F; Wang, ZX; Whittaker, AM; Sirota, E; McMullen, JP or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com