I found the field of Chemistry very interesting. Saw the article Rhodium-Catalyzed [2+1+2+1] Cycloaddition of Benzoic Acids with Diynes through Decarboxylation and C equivalent to C Triple Bond Cleavage published in 2019. Application In Synthesis of 3-Methylbenzoic acid, Reprint Addresses Shibata, Y; Tanaka, K (corresponding author), Tokyo Inst Technol, Dept Chem Sci & Engn, Meguro Ku, Tokyo 1528550, Japan.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid
It has been established that an electron-deficient cyclopentadienyl rhodium(III) ((CpRhIII)-Rh-E) complex catalyzes the oxidative and decarboxylative [2+1+2+1] cycloaddition of benzoic acids with diynes through C equivalent to C triple bond cleavage, leading to fused naphthalenes. This cyclotrimerization is initiated by directed ortho C-H bond cleavage of a benzoic acid, and the subsequent regioselective alkyne insertion and decarboxylation produce a five-membered rhodacycle. The electron-deficient nature of the (CpRhIII)-Rh-E complex promotes reductive elimination giving a cyclobutadiene-rhodium(I) complex rather than the second intermolecular alkyne insertion. The oxidative addition of the thus generated cyclobutadiene to rhodium(I) (formal C equivalent to C triple bond cleavage) followed by the second intramolecular alkyne insertion and reductive elimination give the corresponding [2+1+2+1] cycloaddition product. The synthetic utility of the present [2+1+2+1] cycloaddition was demonstrated in the facile synthesis of a donor-acceptor [5]helicene and a hemi-hexabenzocoronene by a combination with the chemoselective Scholl reaction.
Application In Synthesis of 3-Methylbenzoic acid. Welcome to talk about 99-04-7, If you have any questions, you can contact Honjo, Y; Shibata, Y; Tanaka, K or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com