An article Novel 2-(2,5-methoxy-phenyl) imidazo [4,5-f] – [1,10] phenanthrolin platinum(II) complex display high anticancer activity via dysfunction of mitochondrial signaling pathway WOS:000459840400018 published article about G-QUADRUPLEX DNA; TELOMERASE ACTIVITY; CHIRAL COMPLEXES; CELL APOPTOSIS; II COMPLEXES; LIGANDS; BINDING; INHIBITION; RUTHENIUM; -NO2 in [Bin, Yi-Dong; Yang, Yan; Zhang, Hua-Xin] Guangxi Univ, Sch Chem & Chem Engn, 100 Daxuedong Rd, Nanning 530004, Peoples R China; [Yang, Yan; Luo, Xu-Jian] Yulin Normal Univ, Coll Chem & Food Sci, Guangxi Key Lab Agr Resources Chem & Biotechnol, 1303 Jiaoyudong Rd, Yulin 537000, Peoples R China in 2019.0, Cited 33.0. Recommanded Product: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7
A novel Pt(II) complex of [Pt-II(MPP)(OPD)]Cl center dot H2O (MPP-Pt) (OPD = o-phenylenediamine) with 2-(2,5-methoxy-phenyl) imidazo [4,5-f]-[1, 10] phenanthrolin (H-MPP) was synthesized and fully characterized. In MPP-Pt complex, the Pt(II) ion adopts a four-coordinated square planar geometry. MPP-Pt exhibited selective cytotoxicity against human carcinoma (A549), hepatoblastoma (Hep-G2), ovarian (SK-OV-3), cervical (HeLa) and gastric adenocarcinoma (MGC80-3) cell lines with IC50 values in the micromolar range (0.31-9.48 mu M), but low cytotoxicity toward HL-7702 normal cells. Various experiments showed that MPP-Pt complex caused cell apoptosis via mitochondrial dysfunction in HeLa cells, as shown by the up-regulation expression of p27, apaf-1, p21, cytochrome c (cyc c) and p53 levels, loss of mitochondrial membrane potential (MMP) and the down-regulation expression of bcl-2 protein level.
Welcome to talk about 93-02-7, If you have any questions, you can contact Bin, YD; Yang, Y; Luo, XJ; Zhang, HX or send Email.. Recommanded Product: 93-02-7
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com