Recently I am researching about MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; CANCER; REVERSAL; MODULATORS; MECHANISMS; AGENTS; CELLS, Saw an article supported by the National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China [2018ZX09711002]; Shanghai Institute of Materia Medica Chinese Academy of Science and Fudan University Shanghai Cancer Center. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Wan, Q; Jin, X; Guo, YL; Yu, ZH; Guo, SQ; Morris-Natschke, S; Lee, KH; Liu, HR; Chen, Y. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid. Name: 2,6-Difluorobenzoic acid
Thirty-four seco-3’R,4’R-disubstituted-2′,2′-dimethyldihydropyrano[2,3-f]chromone (seco-DSP) derivatives were designed, synthesized and evaluated for chemo-reversal activity when combined with paclitaxel or vincristine in P-gp overexpressing A2780/T and KB-VIN drug-resistant cancer cell lines. Most of the compounds displayed moderate to significant MDR reversal activities. Compound 7e showed the most potent chemo-sensitization activity with more than 1471 reversal ratio at a concentration of 10 mu M, which was higher than verapamil (VRP) (212-fold). Unexpectedly the newly synthesized compounds did not show chemosensitization activities in a non-P-gp overexpressing cisplatin resistant human ovarian cancer cell line (A2780/CDDP), implying that the MDR reversal effects might be associated with P-gp overexpression. Moreover, the compounds did not exhibit significant anti-proliferative activities against non-tumorigenic cell lines (HUVEC, HOSEC and T29) compared to VRP at the tested concentration and might be safer than VRP. In preliminary pharmacological mechanism studies, the compounds increased accumulation of DOX and promoted P-gp ATPase activity in A2780/T cell lines. Western blot analysis indicated they did not affect the expression level of P-gp in the tested MDR cell lines. Thus, further studies on these seco-DSP derivatives are merited with the goal of developing a desirable chemosensitizer drug candidate. (C) 2020 Elsevier Masson SAS. All rights reserved.
Name: 2,6-Difluorobenzoic acid. Welcome to talk about 385-00-2, If you have any questions, you can contact Wan, Q; Jin, X; Guo, YL; Yu, ZH; Guo, SQ; Morris-Natschke, S; Lee, KH; Liu, HR; Chen, Y or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com