Archives for Chemistry Experiments of 99-04-7

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HPLC of Formula: C8H8O2. Authors Kunova, A; Palazzolo, L; Forlani, F; Catinella, G; Musso, L; Cortesi, P; Eberini, I; Pinto, A; Dallavalle, S in MDPI published article about in [Kunova, Andrea; Forlani, Fabio; Catinella, Giorgia; Musso, Loana; Cortesi, Paolo; Pinto, Andrea; Dallavalle, Sabrina] Univ Milan, Dept Food Environm & Nutr Sci DeFENS, I-20133 Milan, Italy; [Palazzolo, Luca; Eberini, Ivano] Univ Milan, Dept Pharmacol & Biomol Sci DiSFeB, I-20133 Milan, Italy; [Eberini, Ivano] Univ Milan, Data Sci Res Ctr DSRC, I-20133 Milan, Italy in 2021, Cited 41. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

The increasing emergence of fungicide-resistant pathogens requires urgent solutions for crop disease management. Here, we describe a structural investigation of new fungicides obtained by combining strobilurin and succinate dehydrogenase inhibitor pharmacophores. We identified compounds endowed with very good activity against wild-type Pyricularia oryzae, combined in some cases with promising activity against strobilurin-resistant strains. The first three-dimensional model of P. oryzae cytochrome bc1 complex containing azoxystrobin as a ligand was developed. The model was validated with a set of commercially available strobilurins, and it well explains both the resistance mechanism to strobilurins mediated by the mutation G143A and the activity of metyltetraprole against strobilurin-resistant strains. The obtained results shed light on the key recognition determinants of strobilurin-like derivatives in the cytochrome bc1 active site and will guide the further rational design of new fungicides able to overcome resistance caused by G143A mutation in the rice blast pathogen.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com