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An article One-pot, solvent-free Pd(II)-catalyzed direct beta-C-H arylation of carboxamides involving anhydrides as substrates via in situ installation of directing group WOS:000459522800016 published article about UNACTIVATED C(SP(3))-H BONDS; CATALYZED ARYLATION; PALLADIUM(II)-CATALYZED ARYLATION; ALIPHATIC AMIDES; CARBOXYLIC-ACIDS; PALLADIUM; BIDENTATE; FUNCTIONALIZATION; ACTIVATION; AUXILIARY in [Dalal, Arup; Singh, Prabhakar; Babu, Srinivasarao Arulananda] Indian Inst Sci Educ & Res USER Mohali, Dept Chem Sci, Sect 81,Manauli PO, Manauli 140306, Punjab, India in 2019, Cited 75. Recommanded Product: Benzoic anhydride. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0

A one-pot, multicomponent-type, solvent-free Pd(II)-catalyzed direct beta-C-H activation/arylation of carboxamides involving anhydrides as substrates via in situ installation of directing group (DG) is reported. Typically, the DG-assisted beta-C-H activation/arylation of carboxamides is a two-step process comprising the installation of DG and Pd(II)-catalyzed C-H arylation. We attempted a multicomponent-type reaction comprising an anhydride, a DG (e.g. 8-aminoquinoline), an aryl iodide in the presence of the Pd(II) catalyst and an appropriate additive. Different anhydrides, DGs, aryl iodides, catalysts and additives were screened to reveal the scope of this multicomponent-type C-H arylation reaction process and various beta-C-H arylated carboxamides were obtained in satisfactory to good yields. (C) 2019 Elsevier Ltd. All rights reserved.

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Reference:
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