Product Details of 99-04-7. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents published in 2020, Reprint Addresses Liang, CW; Wang, HY; Zhang, TY (corresponding author), Jilin Med Univ, Jilin 132013, Jilin, Peoples R China.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid.
Twenty benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety were synthesized and evaluated for their anti-oxidant and anti-inflammatory activities. Among these compounds, 8h and 81 were appeared to have high radical scavenging efficacies as 0.05 +/- 0.02 and 0.07 +/- 0.03 mmol/L of IC50, values in ABTS(+center dot) bioassay, respectively. In anti-inflammatory tests, compound 8h displayed good activity with 57.35% inhibition after intraperitoneal administration, which was more potent than the reference drug (indomethacin). Molecular modeling studies were performed to investigate the binding mode of the representative compound 8h into COX-2 enzyme. In vitro enzyme study implied that compound 8h exerted its anti-inflammatory activity through COX-2 inhibition.
Welcome to talk about 99-04-7, If you have any questions, you can contact Zheng, XJ; Li, CS; Cui, MY; Song, ZW; Bai, XQ; Liang, CW; Wang, HY; Zhang, TY or send Email.. Product Details of 99-04-7
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com