Day: November 17, 2021

An article Copper-Catalyzed Enantioselective Allylic Alkylation with a gamma-Butyrolactone-Derived Silyl Ketene Acetal WOS:000502594800001 published article about ASYMMETRIC-SYNTHESIS; CONJUGATE ADDITION; ALDOL ADDITIONS; COMPLEXES; LACTONES; REGIOSELECTIVITY; SUBSTITUTION; MECHANISM; BOND in [Jette, Carina, I; Stoltz, Brian M.] CALTECH, Warren & Katharine Schlinger Lab Chem & Chem Engn, Pasadena, CA 91125 USA; [Tong, Z. Jaron; Hadt, Ryan G.] CALTECH, Arthur Amos Noyes Lab Chem Phys, Pasadena, CA 91125 USA in 2020, Cited 45. Product Details of 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Herein, we report a Cu-catalyzed enantioselective allylic alkylation using a gamma-butyrolactone-derived silyl ketene acetal. Critical to the development of this work was the identification of a novel mono-picolinamide ligand with the appropriate steric and electronic properties to afford the desired products in high yield (up to 96 %) and high ee (up to 95 %). Aryl, aliphatic, and unsubstituted allylic chlorides bearing a broad range of functionality are well-tolerated. Spectroscopic studies reveal that a Cu-I species is likely the active catalyst, and DFT calculations suggest ligand sterics play an important role in determining Cu coordination and thus catalyst geometry.

Welcome to talk about 99-04-7, If you have any questions, you can contact Jette, CI; Tong, ZJ; Hadt, RG; Stoltz, BM or send Email.. Product Details of 99-04-7

Reference:
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Authors Uchida, K; Kawamoto, Y; Kobayashi, T; Ito, H in AMER CHEMICAL SOC published article about in [Uchida, Kyohei; Kawamoto, Yuichiro; Kobayashi, Toyoharu; Ito, Hisanaka] Tokyo Univ Pharm & Life Sci, Sch Life Sci, Hachioji, Tokyo 1920392, Japan in 2019.0, Cited 12.0. COA of Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

The first total synthesis of the tricyclic meroterpenoid applanatumol B, isolated from Ganoderma applanatum, was accomplished in 14 steps from 2,5-dimethoxybenzaldehyde and 4-pentyn-1-ol. The synthetic features include an intramolecular Morita-Baylis-Hillman reaction, a stereoselective Michael addition, and efficient construction of the tricyclic skeleton under acidic conditions involving epimerization at the alpha-position of the ketone.

Welcome to talk about 93-02-7, If you have any questions, you can contact Uchida, K; Kawamoto, Y; Kobayashi, T; Ito, H or send Email.. COA of Formula: C9H10O3

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In 2019.0 BIOORG CHEM published article about ENANTIOSELECTIVE SYNTHESIS; DISCOVERY in [Jangir, Nisha; Padhi, Santosh Kumar] Univ Hyderabad, Sch Life Sci, Dept Biochem, Biocatalysis & Enzyme Engn Lab, Hyderabad 500046, Telangana, India in 2019.0, Cited 33.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Recommanded Product: 2,5-Dimethoxybenzaldehyde

Hydroxynitrile lyase (HNL) catalyzed enantioselective C-C bond formation is an efficient approach to synthesize chiral cyanohydrins which are important building blocks in the synthesis of a number of fine chemicals, agrochemicals and pharmaceuticals. Immobilization of HNL is known to provide robustness, reusability and in some cases also enhances activity and selectivity. We optimized the preparation of immobilization of Baliospermium montanum HNL (BmHNL) by cross linking enzyme aggregate (CLEA) method and characterized it by SEM. Optimization of biocatalytic parameters was performed to obtain highest % conversion and ee of (S)-mandelonitrile from benzaldehyde using CLEA-BmHNL. The optimized reaction parameters were: 20 min of reaction time, 7 U of CLEA-BmHNL, 1.2 mM substrate, and 300 mM citrate buffer pH 4.2, that synthesized (S)-mandelonitrile in 99% ee and 60% conversion. Addition of organic solvent in CLEA-BmHNL biocatalysis did not improve in % ee or conversion of product unlike other CLEA-HNLs. CLEA-BmHNL could be successfully reused for eight consecutive cycles without loss of conversion or product formation and five cycles with a little loss in enantioselectivity. Eleven different chiral cyanohydrins were synthesized under optimal biocatalytic conditions in up to 99% ee and 59% conversion, however the % conversion and ee varied for different products. CLEA-BmHNL has improved the enantioselectivity of (S)mandelonitrile synthesis compared to the use of purified BmHNL. Nine aldehydes not tested earlier with BmHNL were converted into their corresponding (S)-cyanohydrins for the first time using CLEA-BmHNL. Among the eleven (S)-cyanohydrins syntheses reported here, eight of them have not been synthesized by any CLEA-HNL. Overall, this study showed preparation, characterization of a stable, robust and recyclable biocatalyst i.e. CLEA-BmHNL and its biocatalytic application in the synthesis of different (S)-aromatic cyanohydrins.

Welcome to talk about 93-02-7, If you have any questions, you can contact Jangir, N; Padhi, SK or send Email.. Recommanded Product: 2,5-Dimethoxybenzaldehyde

Reference:
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Zhang, QH; He, HH; Wang, HB; Zhang, Z; Chen, C in [Zhang, Qiaohong; He, Honghao; Wang, Huibin; Chen, Chen] Ningbo Univ, Sch Mat Sci & Chem Engn, 818 Fenghua Rd, Ningbo 315211, Peoples R China; [Zhang, Zhan] China Tobacco Henan Ind Co Ltd, 8 3rd Ave, Zhengzhou 450001, Peoples R China published Efficient catalytic oxidation of methyl aromatic hydrocarbon with N-alkyl pyridinium salts in 2019, Cited 47. Recommanded Product: 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

A series of N-alkyl pyridinium salts were synthesized and employed as metal-free catalyst for the selective oxidation of methyl aromatic hydrocarbon with molecular oxygen. The electronic effect of the substitutes was found to be an important factor for the catalytic performance. With the introduction of electron-donating substitute -N(CH3)(2), the conversion of p-xylene and selectivity of p-toluic acid could be simultaneously increased. 1-Benzyl-4-N,N-dimethylaminopyridinium salt showed the highest catalytic activity, and 95% conversion with 84% of selectivity to p-toluic acid could be obtained for the selective oxidation of p-xylene. Several methyl aromatic hydrocarbons could all be efficiently oxidized with the reported catalyst at the absence of any metal species.

Welcome to talk about 99-04-7, If you have any questions, you can contact Zhang, QH; He, HH; Wang, HB; Zhang, Z; Chen, C or send Email.. Recommanded Product: 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Song, XJ; Wang, XM; Sun, Q; Huang, ST; Wang, Y in CHINESE JOURNAL STRUCTURAL CHEMISTRY published article about FACILE SYNTHESIS; DERIVATIVES; 1,3,4-THIADIAZOLE; ANTICANCER in [Song Xin-Jian; Huang Sheng-Tian] Sichuan Univ Sci & Engn, Coll Chem & Environm Engn, Zigong 643000, Peoples R China; [Song Xin-Jian; Wang Xu-Mei; Sun Qi; Wang Yan] Hubei Univ Nationalities, Sch Chem & Environm Engn, Enshi 445000, Peoples R China in 2019, Cited 17. SDS of cas: 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N’-((E)-styryl)ureas 4a similar to 4i were designed and synthesized as antitumor agents, and their structures were characterized by IR, H-1 NMR, C-13 NMR, MS and elemental analysis. The single crystal of compound 4a, C17H13FN4OS, was also determined by X-ray crystallography. Crystal data: monoclinic, space group P21/n, a = 4.9401(8), b = 8.7100(15), c = 36.604(6) angstrom, beta = 93.320(3)degrees, V = 1572.4(5) angstrom(3), Z = 4, F(000) = 704, D-c = 1.438 g/cm(3), mu = 0.228 mm(-1), R = 0.0600 and wR = 0.1448 for 2743 independent reflections (R-int = 0.0418) and 2174 observed ones (I > 2 sigma(I)). The in vitro antitumor activities of compounds 4a similar to 4i were preliminarily evaluated by the standard MTT assay.

Welcome to talk about 99-04-7, If you have any questions, you can contact Song, XJ; Wang, XM; Sun, Q; Huang, ST; Wang, Y or send Email.. SDS of cas: 99-04-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Huy, PH; Mbouhom, C in [Huy, Peter H.; Mbouhom, Christelle] Saarland Univ, Inst Organ Chem, POB 151150, D-66041 Saarbrucken, Germany published Formamide catalyzed activation of carboxylic acids – versatile and cost-efficient amidation and esterification in 2019.0, Cited 84.0. Safety of 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

A novel, broadly applicable method for amide C-N and ester C-O bond formation is presented based on formylpyrrolidine (FPyr) as a Lewis base catalyst. Herein, trichlorotriazine (TCT), which is the most cost-efficient reagent for OH-group activation, was employed in amounts of <= 40 mol% with respect to the starting material (100 mol%). The new approach is distinguished by excellent cost-efficiency, waste-balance (E-factor down to 3) and scalability (up to >80 g). Moreover, high levels of functional group compatibility, which includes acid-labile acetals and silyl ethers, are demonstrated and even peptide C-N bonds can be formed. In comparison to reported amidation procedures using TCT, yields are considerably improved (for instance from 26 to 91%) and esterification is facilitated for the first time in synthetically useful yields. These significant enhancements are rationalized by activation by means of acid chlorides instead of less electrophilic acid anhydride intermediates.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Hang, W; Yi, YP; Xi, CJ in AMER CHEMICAL SOC published article about PALLADIUM-CATALYZED CARBOXYLATION; GRIGNARD-REAGENTS; BENZYL CHLORIDES; HALIDES; TRANSFORMATION; COMPLEXES; INSERTION; ALKENES; ESTERS in [Hang, Wei; Yi, Yaping; Xi, Chanjuan] Tsinghua Univ, Dept Chem, MOE Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China; [Xi, Chanjuan] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China in 2020, Cited 56. Formula: C8H8O2. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Cp2TiCl2-catalyzed carboxylation of aryl chlorides with carbon dioxide to afford benzoic acids in good yields has been achieved in the presence of n-BuMgCl. The reaction proceeds by a sequential magnesium halide exchange reaction and carboxylation with CO2 in a wide variety of aryl chlorides under mild conditions.

Formula: C8H8O2. Welcome to talk about 99-04-7, If you have any questions, you can contact Hang, W; Yi, YP; Xi, CJ or send Email.

Reference:
Isothiazole – Wikipedia,
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An article Practical and rapid construction of 2-pyridyl ketone library in continuous flow WOS:000588040300001 published article about ASYMMETRIC HYDROGENATION; NITRIC-ACID; CHEMISTRY; SYSTEM; GENERATION; CONVERSION; NITRATION; ARYL in [Sun, Maolin; Li, Jianchang; Liang, Chaoming; Shan, Chao; Shen, Xinyuan; Ma, Yueyue; Ye, Jinxing] East China Univ Sci & Technol, Minist Educ, Sch Pharm, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China; [Cheng, Ruihua] East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China in 2021, Cited 59. Formula: C8H8O2. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

2-Pyridyl ketones widely appear in bioactive molecules, natural products, and are employed as precursors of chiral 2-pyridine alky/aryl alcohols or 2-aminoalkyl pyridine ligands for asymmetric catalysis. Herein, a practical method for the rapid synthesis of 2-pyridyl ketone library in continuous flow is reported, in which the 2-lithiopyridine formed by Br/Li exchange reacts with commercially available esters to obtain 2-pyridyl ketones in a good yield at short reaction time. This protocol functions broadly on a variety of esters and has been applied to the synthesis of TGF-beta type 1 receptor inhibitor LY580276 intermediate in an environmentally friendly method. It is rapid, reliable, and cost-efficient to afford diverse kinds of 2-pyridyl ketones in the compound library.

Formula: C8H8O2. Welcome to talk about 99-04-7, If you have any questions, you can contact Sun, ML; Li, JC; Liang, CM; Shan, C; Shen, XY; Cheng, RH; Ma, YY; Ye, JX or send Email.

Reference:
Isothiazole – Wikipedia,
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An article Methoxychalcones: Effect of Methoxyl Group on the Antifungal Antibacterial and Antiproliferative Activities WOS:000589443500004 published article about CHALCONE DERIVATIVES; BIOLOGICAL-ACTIVITIES; MOLECULAR-PROPERTIES; LICOCHALCONE; PREDICTION; DISCOVERY; GROWTH; SERIES; AGENTS in [Marques, Beatriz C.; Santos, Mariana B.; Anselmo, Daiane B.; Regasini, Luis O.] Sao Paulo State Univ Unesp, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil; [Monteiro, Diego A.; Gomes, Eleni; Saiki, Marilia F. C.; Rahal, Paula] Sao Paulo State Univ Unesp, Inst Biosci Humanities & Exact Sci, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil; [Rosalen, Pedro L.; Sardi, Janaina C. O.] Univ Campinas Unicamp, Piracicaba Dent Sch, Dept Physiol Sci, BR-13083970 Piracicaba, SP, Brazil in 2020.0, Cited 43.0. Safety of 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Background: Chalcones substituted by methoxyl groups have presented a broad spectrum of bioactivities, including antifungal, antibacterial and antiproliferative effects. However, a clear and unambiguous investigation about the relevance of this substituent on the chalcone framework has not been described. Objective: The purpose of this work is to assess the antibacterial, antifungal and antiproliferative activities of the two series of seventeen synthesized regioisomeric methoxychalcones. Series I and II were constituted by cbalcones substituted by methoxyl groups on rings A (5-12) and B (13-21), respectively. In addition, the library of methoxychalcones was submitted to in silico drug-likeness and pharmacokinetics properties predictions. Methods: Methoxychalcones were synthesized and their structures were confirmed by NMR spectral data analyses. Evaluations of antimicrobial activity were performed against five species of Candida, two Gram-negative and five Gram-positive species. For antiproliferative activity, methoxychalcones were evaluated against four human tumorigenic cell lines, as well as human non-tumorigenic keratinocytes. Drug-likeness and pharmacokinetics properties were predicted using Molinspiration and PreADMET toolkits. Results: In general, chalcones of series I are the most potent antifungal, antibacterial and antiproliferative agents. 3′, 4′, 5′-Trimethoxychalcone (12) demonstrated potent antifungal activity against Candida krusei (MIC = 3.9 mu g/mL), eight times more potent than fluconazole (reference antifungal drug). 3′-Methoxychalcone (6) displayed anti-Pseudomonas activity (MIC = 7.8 mu g/mL). 2′,5′-Dimethoxychalcone (9) displayed potent antiproliferative effect against C-33A (cervix), A-431 (skin) and MCF-7 (breast), with IC50 values ranging from 7.7 to 9.2 mu M. Its potency was superior to curcumin (reference antiproliferative compound), which exhibited IC50 values ranging from 10.4 to 19.0 mu M. Conclusion: Our studies corroborated the relevance of methoxychalcones as antifungal, antibacterial and antiproliferative agents. In addition, we elucidated influence of the position and number of methoxyl groups toward bioactivity. In silico predictions indicated good drug-likeness and pharmacokinetics properties to the library of methoxychalcones.

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Reference:
Isothiazole – Wikipedia,
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An article Palladium-catalyzed salt-free double decarboxylative aryl allylation WOS:000458679200011 published article about CARBOXYLIC-ACIDS; PALLADATION; PERSPECTIVE; OLEFINATION; COMPLEXES in [Daley, Ryan A.; Topczewski, Joseph J.] Univ Minnesota, Dept Chem, Minneapolis, MN 44544 USA in 2019, Cited 26. Recommanded Product: 2,6-Difluorobenzoic acid. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2

This report describes a palladium-catalyzed decarboxylative aryl allylation between unactivated benzoic acids and allylic carbonates. This transformation successfully couples a variety of carbonates and benzoic acids in good yield (up to 94%) using 1 mol% palladium. This salt free allyl-arylation proceeds without added base, copper, or silver. The only stoichiometric byproducts are carbon dioxide and tert-butanol.

Welcome to talk about 385-00-2, If you have any questions, you can contact Daley, RA; Topczewski, JJ or send Email.. Recommanded Product: 2,6-Difluorobenzoic acid

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Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com