Category: isothiazole. I found the field of Chemistry very interesting. Saw the article A one pot protocol to convert nitro-arenes into N-aryl amides published in 2020, Reprint Addresses Benaglia, M (corresponding author), Univ Milan, Dipartimento Chim, Via Golgi 19, I-20133 Milan, Italy.. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride.
A two-step one pot, experimentally simple protocol, based on readily available and inexpensive reagents allowed the conversion of nitro-arenes directly to N-aryl amides. A metal-free reduction of the nitro group, mediated by trichlorosilane, followed by the addition of an anhydride afforded the corresponding N-aryl carboxyamide, that was isolated after a simple aqueous work up in good-excellent yields. When the methodology was applied to the reaction with gamma-butyrolactone, the desired N-aryl butanamide derivative was obtained, featuring a chlorine atom at the gamma-position, a functionalized handle that can be used for further synthetic manipulation of the reaction product. Such an intermediate has already been employed as a key advanced precursor of pharmaceutically active compounds.
Category: isothiazole. Bye, fridends, I hope you can learn more about C14H10O3, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com