Authors Izquierdo, J; Demurget, N; Landa, A; Brinck, T; Mercero, JM; Diner, P; Oiarbide, M; Palomo, C in WILEY-V C H VERLAG GMBH published article about CATALYTIC ENANTIOSELECTIVE SYNTHESIS; HETERO-DIELS-ALDER; CONJUGATE ADDITION; N-OXIDES; QUATERNARY STEREOCENTERS; MANNICH REACTIONS; MUKAIYAMA-ALDOL; DERIVATIVES; PYRIDINE; CONSTRUCTION in [Izquierdo, June; Demurget, Noemie; Landa, Aitor; Oiarbide, Mikel; Palomo, Claudio] Univ Basque Country, Dept Quim Organ 1, UPV EHU, Manuel Lardizabal 3, San Sebastian 20018, Spain; [Brinck, Tore; Diner, Peter] KTH Royal Inst Technol, Dept Chem, Tekn Ringen 30, S-10044 Stockholm, Sweden; [Mercero, Jose M.] Euskal Herriko Unibertsitatea, Kimika Fak, UPV EHU, Donostia San Sebastian, Spain; [Mercero, Jose M.] Donostia Int Phys Ctr DIPC, Donostia San Sebastian, Spain in 2019, Cited 122. Category: isothiazole. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0
A bifunctional amine/squaramide catalyst promoted direct aldol addition of an hydantoin surrogate to pyridine 2-carbaldehyde N-oxides to afford adducts bearing two vicinal tertiary/quaternary carbons in high diastereo- and enantioselectivity (d.r. up to >20:1; ee up to 98 %) is reported. Acid hydrolysis of adducts followed by reduction of the N-oxide group yields enantiopure carbinol-tethered quaternary hydantoin-azaarene conjugates with densely functionalized skeletons. DFT studies of the potential energy surface (B3LYP/6-31+G(d)+CPCM (dichloromethane)) of the reaction correlate the activity of different catalysts and support an intramolecular hydrogen-bond-assisted activation of the squaramide moiety in the transition state of the catalytic reaction.
About Benzoic anhydride, If you have any questions, you can contact Izquierdo, J; Demurget, N; Landa, A; Brinck, T; Mercero, JM; Diner, P; Oiarbide, M; Palomo, C or concate me.. Category: isothiazole
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com